Comparative Diagnostic Evaluation with Contrast-Enhanced Ultrasound, Computed Tomography and Magnetic Resonance Imaging in Patients with Pancreatic Cystic Neoplasms
Ya Sun,1,2,* Shuo Yang,3,* Erpeng Qi,1 Fangyi Liu,1 Fubo Zhou,1 Yuhan Lu,1 Ping Liang,1 Huiyi Ye,4 Xiaoling Yu1 1Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China; 2Department of Ultrasound, Aerospace Central Hospital, Beijing...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-04-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/comparative-diagnostic-evaluation-with-contrast-enhanced-ultrasound-co-peer-reviewed-article-CMAR |
| _version_ | 1818958554924580864 |
|---|---|
| author | Sun Y Yang S Qi E Liu F Zhou F Lu Y Liang P Ye H Yu X |
| author_facet | Sun Y Yang S Qi E Liu F Zhou F Lu Y Liang P Ye H Yu X |
| author_sort | Sun Y |
| collection | DOAJ |
| description | Ya Sun,1,2,* Shuo Yang,3,* Erpeng Qi,1 Fangyi Liu,1 Fubo Zhou,1 Yuhan Lu,1 Ping Liang,1 Huiyi Ye,4 Xiaoling Yu1 1Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China; 2Department of Ultrasound, Aerospace Central Hospital, Beijing 100049, People’s Republic of China; 3Chinese PLA Medical School, Beijing, 100853, People’s Republic of China; 4Radiology Department, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoling YuDepartment of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, People’s Republic of ChinaEmail dyuxl301@aliyun.comPurpose: The purpose of our study was to evaluate the role of contrast-enhanced ultrasound (CEUS) with magnetic resonance imaging (MRI) and computed tomography (CT) in the pathological diagnosis of pancreatic cystic neoplasms (PCNs).Methods: A total of 90 patients (66 women, 24 men) aged 18– 71 years were studied prospectively. CEUS was performed in all patients, whereas MRI was performed in 85 patients and CT in 69 patients. We analyzed the sensitivity and accuracy of these three imaging modalities to diagnose the PCNs. Neoplasm size, location, shape, intralesional mural nodules, septa and duct dilatation were also assessed by different radiologists.Results: There were no significant differences in sensitivity for discriminating PCNs from pancreatic cystic lesions between CEUS and MRI (p=0.614) or between CEUS and CT (p=0.479). The diagnostic accuracy of CEUS for classifying PCNs was 64.4% (58/90), which was higher than that of CT (53.6%, 37/69, P=0.017), and lower than that of MRI (70.6%, 60/85, p=0.791). Regarding tumor size for lesions larger than 3 cm, CEUS was superior to CT in differentiating the specific type of PCN (p=0.041), and CEUS had the same value as MRI (p=0.774). Furthermore, CEUS is valuable for precisely characterizing internal structures, for instance, septa (p=0.003, compared with CT; p=0.443, compared with MRI) and nodules (p= 0.018, compared with CT; p=0.033, compared with MRI). The number of septa (p=0.033) and cyst morphology (p=0.016) were meaningful indicators in differentiating serous and mucinous adenoma. There was no significant difference in evaluating size and detecting duct dilatation among the three imaging methods.Conclusion: CEUS compares favorably with MRI in displaying the inner structure of PCNs and offers advantages over CT. CEUS can contribute in an important way to the diagnosis of pancreatic cystic neoplasms.Keywords: contrast-enhanced ultrasound, computed tomography, magnetic resonance imaging, pancreatic cystic neoplasms, diagnostic evaluation |
| first_indexed | 2024-12-20T11:27:36Z |
| format | Article |
| id | doaj.art-7b4910ef57684cc7a1df5f2663fffa02 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-20T11:27:36Z |
| publishDate | 2020-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-7b4910ef57684cc7a1df5f2663fffa022022-12-21T19:42:19ZengDove Medical PressCancer Management and Research1179-13222020-04-01Volume 122889289853364Comparative Diagnostic Evaluation with Contrast-Enhanced Ultrasound, Computed Tomography and Magnetic Resonance Imaging in Patients with Pancreatic Cystic NeoplasmsSun YYang SQi ELiu FZhou FLu YLiang PYe HYu XYa Sun,1,2,* Shuo Yang,3,* Erpeng Qi,1 Fangyi Liu,1 Fubo Zhou,1 Yuhan Lu,1 Ping Liang,1 Huiyi Ye,4 Xiaoling Yu1 1Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China; 2Department of Ultrasound, Aerospace Central Hospital, Beijing 100049, People’s Republic of China; 3Chinese PLA Medical School, Beijing, 100853, People’s Republic of China; 4Radiology Department, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoling YuDepartment of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, People’s Republic of ChinaEmail dyuxl301@aliyun.comPurpose: The purpose of our study was to evaluate the role of contrast-enhanced ultrasound (CEUS) with magnetic resonance imaging (MRI) and computed tomography (CT) in the pathological diagnosis of pancreatic cystic neoplasms (PCNs).Methods: A total of 90 patients (66 women, 24 men) aged 18– 71 years were studied prospectively. CEUS was performed in all patients, whereas MRI was performed in 85 patients and CT in 69 patients. We analyzed the sensitivity and accuracy of these three imaging modalities to diagnose the PCNs. Neoplasm size, location, shape, intralesional mural nodules, septa and duct dilatation were also assessed by different radiologists.Results: There were no significant differences in sensitivity for discriminating PCNs from pancreatic cystic lesions between CEUS and MRI (p=0.614) or between CEUS and CT (p=0.479). The diagnostic accuracy of CEUS for classifying PCNs was 64.4% (58/90), which was higher than that of CT (53.6%, 37/69, P=0.017), and lower than that of MRI (70.6%, 60/85, p=0.791). Regarding tumor size for lesions larger than 3 cm, CEUS was superior to CT in differentiating the specific type of PCN (p=0.041), and CEUS had the same value as MRI (p=0.774). Furthermore, CEUS is valuable for precisely characterizing internal structures, for instance, septa (p=0.003, compared with CT; p=0.443, compared with MRI) and nodules (p= 0.018, compared with CT; p=0.033, compared with MRI). The number of septa (p=0.033) and cyst morphology (p=0.016) were meaningful indicators in differentiating serous and mucinous adenoma. There was no significant difference in evaluating size and detecting duct dilatation among the three imaging methods.Conclusion: CEUS compares favorably with MRI in displaying the inner structure of PCNs and offers advantages over CT. CEUS can contribute in an important way to the diagnosis of pancreatic cystic neoplasms.Keywords: contrast-enhanced ultrasound, computed tomography, magnetic resonance imaging, pancreatic cystic neoplasms, diagnostic evaluationhttps://www.dovepress.com/comparative-diagnostic-evaluation-with-contrast-enhanced-ultrasound-co-peer-reviewed-article-CMARcontrast-enhanced ultrasoundcomputed tomographymagnetic resonance imagingpancreatic cystic neoplasmsdiagnostic evaluation |
| spellingShingle | Sun Y Yang S Qi E Liu F Zhou F Lu Y Liang P Ye H Yu X Comparative Diagnostic Evaluation with Contrast-Enhanced Ultrasound, Computed Tomography and Magnetic Resonance Imaging in Patients with Pancreatic Cystic Neoplasms Cancer Management and Research contrast-enhanced ultrasound computed tomography magnetic resonance imaging pancreatic cystic neoplasms diagnostic evaluation |
| title | Comparative Diagnostic Evaluation with Contrast-Enhanced Ultrasound, Computed Tomography and Magnetic Resonance Imaging in Patients with Pancreatic Cystic Neoplasms |
| title_full | Comparative Diagnostic Evaluation with Contrast-Enhanced Ultrasound, Computed Tomography and Magnetic Resonance Imaging in Patients with Pancreatic Cystic Neoplasms |
| title_fullStr | Comparative Diagnostic Evaluation with Contrast-Enhanced Ultrasound, Computed Tomography and Magnetic Resonance Imaging in Patients with Pancreatic Cystic Neoplasms |
| title_full_unstemmed | Comparative Diagnostic Evaluation with Contrast-Enhanced Ultrasound, Computed Tomography and Magnetic Resonance Imaging in Patients with Pancreatic Cystic Neoplasms |
| title_short | Comparative Diagnostic Evaluation with Contrast-Enhanced Ultrasound, Computed Tomography and Magnetic Resonance Imaging in Patients with Pancreatic Cystic Neoplasms |
| title_sort | comparative diagnostic evaluation with contrast enhanced ultrasound computed tomography and magnetic resonance imaging in patients with pancreatic cystic neoplasms |
| topic | contrast-enhanced ultrasound computed tomography magnetic resonance imaging pancreatic cystic neoplasms diagnostic evaluation |
| url | https://www.dovepress.com/comparative-diagnostic-evaluation-with-contrast-enhanced-ultrasound-co-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT suny comparativediagnosticevaluationwithcontrastenhancedultrasoundcomputedtomographyandmagneticresonanceimaginginpatientswithpancreaticcysticneoplasms AT yangs comparativediagnosticevaluationwithcontrastenhancedultrasoundcomputedtomographyandmagneticresonanceimaginginpatientswithpancreaticcysticneoplasms AT qie comparativediagnosticevaluationwithcontrastenhancedultrasoundcomputedtomographyandmagneticresonanceimaginginpatientswithpancreaticcysticneoplasms AT liuf comparativediagnosticevaluationwithcontrastenhancedultrasoundcomputedtomographyandmagneticresonanceimaginginpatientswithpancreaticcysticneoplasms AT zhouf comparativediagnosticevaluationwithcontrastenhancedultrasoundcomputedtomographyandmagneticresonanceimaginginpatientswithpancreaticcysticneoplasms AT luy comparativediagnosticevaluationwithcontrastenhancedultrasoundcomputedtomographyandmagneticresonanceimaginginpatientswithpancreaticcysticneoplasms AT liangp comparativediagnosticevaluationwithcontrastenhancedultrasoundcomputedtomographyandmagneticresonanceimaginginpatientswithpancreaticcysticneoplasms AT yeh comparativediagnosticevaluationwithcontrastenhancedultrasoundcomputedtomographyandmagneticresonanceimaginginpatientswithpancreaticcysticneoplasms AT yux comparativediagnosticevaluationwithcontrastenhancedultrasoundcomputedtomographyandmagneticresonanceimaginginpatientswithpancreaticcysticneoplasms |