Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population
Introduction: Premature ejaculation (PE) is widely regarded as one of the most common sexual dysfunctions in men. The neurobiogenesis of PE is complex and involves the serotoninergic (5-HT) system. Aim: In this study, we investigated whether polymorphisms in the tryptophan hydroxylase 2 (TPH2) gene...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2020-06-01
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| Series: | Sexual Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2050116120300271 |
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| author | Xu Fu, MD Xiansheng Zhang, MD, PhD Tao Jiang, MD Yuanyuan Huang, MD Peng Cheng, MD Dongdong Tang, MD Jingjing Gao, MD JunHua Du, MD |
| author_facet | Xu Fu, MD Xiansheng Zhang, MD, PhD Tao Jiang, MD Yuanyuan Huang, MD Peng Cheng, MD Dongdong Tang, MD Jingjing Gao, MD JunHua Du, MD |
| author_sort | Xu Fu, MD |
| collection | DOAJ |
| description | Introduction: Premature ejaculation (PE) is widely regarded as one of the most common sexual dysfunctions in men. The neurobiogenesis of PE is complex and involves the serotoninergic (5-HT) system. Aim: In this study, we investigated whether polymorphisms in the tryptophan hydroxylase 2 (TPH2) gene were associated with lifelong PE (LPE). Methods: A total of 121 men diagnosed with LPE were recruited from our outpatient clinics and 94 healthy controls from the health examination center. Intravaginal ejaculation latency time (IELT) was measured using a stopwatch. The PE diagnostic tool (PEDT) data were collected at the same time. All subjects with LPE and healthy controls were genotyped for polymorphisms in the TPH2 gene. Allele and genotype frequencies of single-nucleotide polymorphisms (SNPs) were compared between the patients and controls. Main Outcome Measure: The main outcome measures are IELT and PEDT to diagnose LPE. The association of LPE with TPH2 gene polymorphisms in these areas was investigated. Results: The IELT, PEDT scores, and education levels in the LPE group were significantly different from those in the control group. Statistically significant differences were found in the SNPs of SNV019 and rs4290270. The frequencies of the G allele and G/A genotype of SNV019 were significantly higher in the patients with LPE than in the controls (P = .045 and .037, respectively). The A allele and A/A genotype of rs4290270 were more frequent in the patients with LPE than in the controls (P = .037 and .049, respectively). In the dominant model of inheritance, the SNV019 polymorphism in the patients with LPE was significantly different from that in the controls (odds ratio [95% confidence interval] = 2.936 [1.066–8.084], P = .037). In men with LPE, there was no statistically significant association between genotype and median IELT. Conclusion: The SNPs SNV019 and rs4290270 of the TPH2 gene seemed to be associated with LPE in the Han population. Men with the A allele of SNV019 or the T allele of rs4290270 may be less likely to suffer from LPE.Fu X, Zhang X, Jiang T, et al. Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population. Sex Med 2020;8:223–229. |
| first_indexed | 2024-03-12T08:09:51Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2050-1161 |
| language | English |
| last_indexed | 2024-03-12T08:09:51Z |
| publishDate | 2020-06-01 |
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| spelling | doaj.art-7b4a9edb61ae408ab8742fda5f27bea82023-09-02T19:11:33ZengOxford University PressSexual Medicine2050-11612020-06-0182223229Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han PopulationXu Fu, MD0Xiansheng Zhang, MD, PhD1Tao Jiang, MD2Yuanyuan Huang, MD3Peng Cheng, MD4Dongdong Tang, MD5Jingjing Gao, MD6JunHua Du, MD7Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Corresponding Author: Xiansheng Zhang, MD, PhD, Department of Urology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China. Tel: 86-551-62922046; Fax: 86-551-62922046Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaIntroduction: Premature ejaculation (PE) is widely regarded as one of the most common sexual dysfunctions in men. The neurobiogenesis of PE is complex and involves the serotoninergic (5-HT) system. Aim: In this study, we investigated whether polymorphisms in the tryptophan hydroxylase 2 (TPH2) gene were associated with lifelong PE (LPE). Methods: A total of 121 men diagnosed with LPE were recruited from our outpatient clinics and 94 healthy controls from the health examination center. Intravaginal ejaculation latency time (IELT) was measured using a stopwatch. The PE diagnostic tool (PEDT) data were collected at the same time. All subjects with LPE and healthy controls were genotyped for polymorphisms in the TPH2 gene. Allele and genotype frequencies of single-nucleotide polymorphisms (SNPs) were compared between the patients and controls. Main Outcome Measure: The main outcome measures are IELT and PEDT to diagnose LPE. The association of LPE with TPH2 gene polymorphisms in these areas was investigated. Results: The IELT, PEDT scores, and education levels in the LPE group were significantly different from those in the control group. Statistically significant differences were found in the SNPs of SNV019 and rs4290270. The frequencies of the G allele and G/A genotype of SNV019 were significantly higher in the patients with LPE than in the controls (P = .045 and .037, respectively). The A allele and A/A genotype of rs4290270 were more frequent in the patients with LPE than in the controls (P = .037 and .049, respectively). In the dominant model of inheritance, the SNV019 polymorphism in the patients with LPE was significantly different from that in the controls (odds ratio [95% confidence interval] = 2.936 [1.066–8.084], P = .037). In men with LPE, there was no statistically significant association between genotype and median IELT. Conclusion: The SNPs SNV019 and rs4290270 of the TPH2 gene seemed to be associated with LPE in the Han population. Men with the A allele of SNV019 or the T allele of rs4290270 may be less likely to suffer from LPE.Fu X, Zhang X, Jiang T, et al. Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population. Sex Med 2020;8:223–229.http://www.sciencedirect.com/science/article/pii/S2050116120300271Lifelong Premature EjaculationSerotoninTryptophan Hydroxylase 2Single Nucleotide Polymorphism |
| spellingShingle | Xu Fu, MD Xiansheng Zhang, MD, PhD Tao Jiang, MD Yuanyuan Huang, MD Peng Cheng, MD Dongdong Tang, MD Jingjing Gao, MD JunHua Du, MD Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population Sexual Medicine Lifelong Premature Ejaculation Serotonin Tryptophan Hydroxylase 2 Single Nucleotide Polymorphism |
| title | Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population |
| title_full | Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population |
| title_fullStr | Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population |
| title_full_unstemmed | Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population |
| title_short | Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population |
| title_sort | association between lifelong premature ejaculation and polymorphism of tryptophan hydroxylase 2 gene in the han population |
| topic | Lifelong Premature Ejaculation Serotonin Tryptophan Hydroxylase 2 Single Nucleotide Polymorphism |
| url | http://www.sciencedirect.com/science/article/pii/S2050116120300271 |
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