Brainstem glioma: Clinical significance and prognostic evaluation
In the present study, we have determined the prognostic value and observed the clinicopathological features of brainstem glioma. Overall, we found more number of male patients with brainstem glioma (male:female ratio: 1:6). All patients were subjected to surgery followed by chemotherapy. The tumor w...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-06-01
|
| Series: | Interdisciplinary Neurosurgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221475191830255X |
| _version_ | 1818469334647832576 |
|---|---|
| author | Ravindra Pramod Deshpande Y.B.V.K. Chandrasekhar Deepak Babu I. Satish Rao Manas Panigrahi Phanithi Prakash Babu |
| author_facet | Ravindra Pramod Deshpande Y.B.V.K. Chandrasekhar Deepak Babu I. Satish Rao Manas Panigrahi Phanithi Prakash Babu |
| author_sort | Ravindra Pramod Deshpande |
| collection | DOAJ |
| description | In the present study, we have determined the prognostic value and observed the clinicopathological features of brainstem glioma. Overall, we found more number of male patients with brainstem glioma (male:female ratio: 1:6). All patients were subjected to surgery followed by chemotherapy. The tumor was mainly located at brainstem and thalamus. We have recorded the symptoms associated with onset of lesions and predominated by headache, vomiting and limb weakness. We observed the overall survival pattern in brain stem glioma cases and further among low and high grade subgroups. Patients with high grade brainstem glioma were recorded with the median survival of 15 months. There was a statistically significant difference in the survival pattern of low grade vs high grade group (p = 0.015, hazard ratio: 0.29, 95% CI of ratio: 0.058 to 0.71) Taken together, the clinical presentation provides valuable information to enhance the therapeutic measures for the brainstem glioma cases. Keywords: Brainstem, Glioma, Surgery |
| first_indexed | 2024-04-13T21:23:13Z |
| format | Article |
| id | doaj.art-7b4b48a45b224d2aaf6a879c5709b6fe |
| institution | Directory Open Access Journal |
| issn | 2214-7519 |
| language | English |
| last_indexed | 2024-04-13T21:23:13Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj.art-7b4b48a45b224d2aaf6a879c5709b6fe2022-12-22T02:29:25ZengElsevierInterdisciplinary Neurosurgery2214-75192019-06-01166466Brainstem glioma: Clinical significance and prognostic evaluationRavindra Pramod Deshpande0Y.B.V.K. Chandrasekhar1Deepak Babu2I. Satish Rao3Manas Panigrahi4Phanithi Prakash Babu5Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State, IndiaDepartment of Neurosurgery, Krishna Institute of Medical Sciences, Secunderabad, Telangana State, IndiaDepartment of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State, IndiaDepartment of Pathology, Krishna Institute of Medical Sciences, Secunderabad, Telangana State, IndiaDepartment of Neurosurgery, Krishna Institute of Medical Sciences, Secunderabad, Telangana State, IndiaDepartment of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State, India; Corresponding author at: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500046, Telangana State, India.In the present study, we have determined the prognostic value and observed the clinicopathological features of brainstem glioma. Overall, we found more number of male patients with brainstem glioma (male:female ratio: 1:6). All patients were subjected to surgery followed by chemotherapy. The tumor was mainly located at brainstem and thalamus. We have recorded the symptoms associated with onset of lesions and predominated by headache, vomiting and limb weakness. We observed the overall survival pattern in brain stem glioma cases and further among low and high grade subgroups. Patients with high grade brainstem glioma were recorded with the median survival of 15 months. There was a statistically significant difference in the survival pattern of low grade vs high grade group (p = 0.015, hazard ratio: 0.29, 95% CI of ratio: 0.058 to 0.71) Taken together, the clinical presentation provides valuable information to enhance the therapeutic measures for the brainstem glioma cases. Keywords: Brainstem, Glioma, Surgeryhttp://www.sciencedirect.com/science/article/pii/S221475191830255X |
| spellingShingle | Ravindra Pramod Deshpande Y.B.V.K. Chandrasekhar Deepak Babu I. Satish Rao Manas Panigrahi Phanithi Prakash Babu Brainstem glioma: Clinical significance and prognostic evaluation Interdisciplinary Neurosurgery |
| title | Brainstem glioma: Clinical significance and prognostic evaluation |
| title_full | Brainstem glioma: Clinical significance and prognostic evaluation |
| title_fullStr | Brainstem glioma: Clinical significance and prognostic evaluation |
| title_full_unstemmed | Brainstem glioma: Clinical significance and prognostic evaluation |
| title_short | Brainstem glioma: Clinical significance and prognostic evaluation |
| title_sort | brainstem glioma clinical significance and prognostic evaluation |
| url | http://www.sciencedirect.com/science/article/pii/S221475191830255X |
| work_keys_str_mv | AT ravindrapramoddeshpande brainstemgliomaclinicalsignificanceandprognosticevaluation AT ybvkchandrasekhar brainstemgliomaclinicalsignificanceandprognosticevaluation AT deepakbabu brainstemgliomaclinicalsignificanceandprognosticevaluation AT isatishrao brainstemgliomaclinicalsignificanceandprognosticevaluation AT manaspanigrahi brainstemgliomaclinicalsignificanceandprognosticevaluation AT phanithiprakashbabu brainstemgliomaclinicalsignificanceandprognosticevaluation |