Current problems of synaptic plasticity
The present review focuses on the results of modern studies confirming the last century ideas about the effect of neuron discharge on the effectiveness of its synaptic inputs. This concept is being developed now at the receptor, channel and intracellular levels, which allows to reveal the special ro...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2018-12-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/563/453 |
| _version_ | 1811244274462752768 |
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| author | Vladimir G. Skrebitsky Irina N. Sharonova |
| author_facet | Vladimir G. Skrebitsky Irina N. Sharonova |
| author_sort | Vladimir G. Skrebitsky |
| collection | DOAJ |
| description | The present review focuses on the results of modern studies confirming the last century ideas about the effect of neuron discharge on the effectiveness of its synaptic inputs. This concept is being developed now at the receptor, channel and intracellular levels, which allows to reveal the special role of calcium ions in the activation of a number of cascades leading to transient or long-lasting changes in synaptic transmission. An important role of various physiologically active compounds that affect synaptic plasticity and, through it, the cognitive processes in humans is emphasized, which has not only fundamental, but also applied significance. Cellular and receptor targets of nootropic drugs aimed at the correction of various types of cognitive impairment are specifically considered |
| first_indexed | 2024-04-12T14:23:13Z |
| format | Article |
| id | doaj.art-7b4bcf6f34d7437496c5e688c11898c0 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-12T14:23:13Z |
| publishDate | 2018-12-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-7b4bcf6f34d7437496c5e688c11898c02022-12-22T03:29:32ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332018-12-01125S606910.25692/ACEN.2018.5.8434Current problems of synaptic plasticityVladimir G. Skrebitsky0Irina N. Sharonova1https://orcid.org/0000-0001-9955-1870Research Center of NeurologyResearch Center of NeurologyThe present review focuses on the results of modern studies confirming the last century ideas about the effect of neuron discharge on the effectiveness of its synaptic inputs. This concept is being developed now at the receptor, channel and intracellular levels, which allows to reveal the special role of calcium ions in the activation of a number of cascades leading to transient or long-lasting changes in synaptic transmission. An important role of various physiologically active compounds that affect synaptic plasticity and, through it, the cognitive processes in humans is emphasized, which has not only fundamental, but also applied significance. Cellular and receptor targets of nootropic drugs aimed at the correction of various types of cognitive impairment are specifically consideredhttps://annaly-nevrologii.com/journal/pathID/article/viewFile/563/453synaptic plasticityhebbian synapseslong-term potentiationdisinhibitionneuropeptidesnootropics |
| spellingShingle | Vladimir G. Skrebitsky Irina N. Sharonova Current problems of synaptic plasticity Анналы клинической и экспериментальной неврологии synaptic plasticity hebbian synapses long-term potentiation disinhibition neuropeptides nootropics |
| title | Current problems of synaptic plasticity |
| title_full | Current problems of synaptic plasticity |
| title_fullStr | Current problems of synaptic plasticity |
| title_full_unstemmed | Current problems of synaptic plasticity |
| title_short | Current problems of synaptic plasticity |
| title_sort | current problems of synaptic plasticity |
| topic | synaptic plasticity hebbian synapses long-term potentiation disinhibition neuropeptides nootropics |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/563/453 |
| work_keys_str_mv | AT vladimirgskrebitsky currentproblemsofsynapticplasticity AT irinansharonova currentproblemsofsynapticplasticity |