Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and Outcome
In this case report, we describe the diagnosis, treatment, and outcome of two feline cases of vertebral osteosarcoma. Case 1: A 6-year-old female neutered domestic longhaired cat was presented with progressive paraparesis, ataxia, and spinal hyperesthesia. MRI of the thoracolumbar spinal cord and ve...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/22/3478 |
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| author | Koen Maurits Santifort Martijn Beukers Arno Roos Benjamin van Rijswoud Nadine Meertens Klaas Peperkamp Ron Ben-Amotz Niklas Bergknut |
| author_facet | Koen Maurits Santifort Martijn Beukers Arno Roos Benjamin van Rijswoud Nadine Meertens Klaas Peperkamp Ron Ben-Amotz Niklas Bergknut |
| author_sort | Koen Maurits Santifort |
| collection | DOAJ |
| description | In this case report, we describe the diagnosis, treatment, and outcome of two feline cases of vertebral osteosarcoma. Case 1: A 6-year-old female neutered domestic longhaired cat was presented with progressive paraparesis, ataxia, and spinal hyperesthesia. MRI of the thoracolumbar spinal cord and vertebral column revealed a strongly contrast-enhancing mass lesion originating from the dorsal lamina and spinous process of T13. The lesion caused extradural compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation of surgical biopsies was consistent with vertebral osteosarcoma. The cat was paraplegic with intact nociception post-surgery. Subsequently, the cat recovered ambulation while remaining mildly ataxic and paraparetic at long-term follow-up. Post-operative chemotherapy was started with doxorubicin. CT scans at 2, 4, 9, 13, and 20 months post-surgery showed no signs of local recurrence or metastasis. Case 2: A 15.5-year-old male neutered domestic shorthaired cat was presented with progressive paraparesis, tail paresis, and spinal hyperesthesia. Radiographs and CT scan of the lumbar vertebral column showed a large mass originating from the dorsal lamina and spinous process of L6, suggestive of neoplasia, with severe compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation was consistent with vertebral osteosarcoma. Post-operative chemotherapy was started with doxorubicin. Seven months post-surgery, the patient was neurologically normal with no signs of metastatic disease. This case report highlights the possibility of good outcomes after the surgical treatment of feline vertebral osteosarcoma supplemented with post-surgical chemotherapy. |
| first_indexed | 2024-03-09T17:05:29Z |
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| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T17:05:29Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-7b4d15577d754849b9eb8f94b63b84a92023-11-24T14:24:40ZengMDPI AGAnimals2076-26152023-11-011322347810.3390/ani13223478Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and OutcomeKoen Maurits Santifort0Martijn Beukers1Arno Roos2Benjamin van Rijswoud3Nadine Meertens4Klaas Peperkamp5Ron Ben-Amotz6Niklas Bergknut7IVC Evidensia Small Animal Referral Hospital Arnhem, 6825 MB Arnhem, The NetherlandsIVC Evidensia Small Animal Referral Hospital Hart van Brabant, 5144 AM Waalwijk, The NetherlandsIVC Evidensia Small Animal Referral Hospital Nieuwegein, 3433 NP Nieuwegein, The NetherlandsIVC Evidensia Small Animal Referral Hospital Arnhem, 6825 MB Arnhem, The NetherlandsDepartment of Pathology, Royal GD, 7418 EZ Deventer, The NetherlandsDepartment of Pathology, Royal GD, 7418 EZ Deventer, The NetherlandsIVC Evidensia Small Animal Referral Hospital Hart van Brabant, 5144 AM Waalwijk, The NetherlandsIVC Evidensia Small Animal Referral Hospital Hart van Brabant, 5144 AM Waalwijk, The NetherlandsIn this case report, we describe the diagnosis, treatment, and outcome of two feline cases of vertebral osteosarcoma. Case 1: A 6-year-old female neutered domestic longhaired cat was presented with progressive paraparesis, ataxia, and spinal hyperesthesia. MRI of the thoracolumbar spinal cord and vertebral column revealed a strongly contrast-enhancing mass lesion originating from the dorsal lamina and spinous process of T13. The lesion caused extradural compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation of surgical biopsies was consistent with vertebral osteosarcoma. The cat was paraplegic with intact nociception post-surgery. Subsequently, the cat recovered ambulation while remaining mildly ataxic and paraparetic at long-term follow-up. Post-operative chemotherapy was started with doxorubicin. CT scans at 2, 4, 9, 13, and 20 months post-surgery showed no signs of local recurrence or metastasis. Case 2: A 15.5-year-old male neutered domestic shorthaired cat was presented with progressive paraparesis, tail paresis, and spinal hyperesthesia. Radiographs and CT scan of the lumbar vertebral column showed a large mass originating from the dorsal lamina and spinous process of L6, suggestive of neoplasia, with severe compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation was consistent with vertebral osteosarcoma. Post-operative chemotherapy was started with doxorubicin. Seven months post-surgery, the patient was neurologically normal with no signs of metastatic disease. This case report highlights the possibility of good outcomes after the surgical treatment of feline vertebral osteosarcoma supplemented with post-surgical chemotherapy.https://www.mdpi.com/2076-2615/13/22/3478osteosarcomafelineoutcometreatmentchemotherapysurgery |
| spellingShingle | Koen Maurits Santifort Martijn Beukers Arno Roos Benjamin van Rijswoud Nadine Meertens Klaas Peperkamp Ron Ben-Amotz Niklas Bergknut Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and Outcome Animals osteosarcoma feline outcome treatment chemotherapy surgery |
| title | Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and Outcome |
| title_full | Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and Outcome |
| title_fullStr | Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and Outcome |
| title_full_unstemmed | Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and Outcome |
| title_short | Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and Outcome |
| title_sort | vertebral osteosarcoma in two cats diagnosis treatment and outcome |
| topic | osteosarcoma feline outcome treatment chemotherapy surgery |
| url | https://www.mdpi.com/2076-2615/13/22/3478 |
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