Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study
Abstract Background Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization. We compared HRQL among persons with initial mild, moderate or s...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12916-022-02615-7 |
| _version_ | 1797984677512871936 |
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| author | Anouk Verveen Elke Wynberg Hugo D. G. van Willigen Udi Davidovich Anja Lok Eric P. Moll van Charante Menno D. de Jong Godelieve de Bree Maria Prins Hans Knoop Pythia T. Nieuwkerk the RECoVERED Study Group |
| author_facet | Anouk Verveen Elke Wynberg Hugo D. G. van Willigen Udi Davidovich Anja Lok Eric P. Moll van Charante Menno D. de Jong Godelieve de Bree Maria Prins Hans Knoop Pythia T. Nieuwkerk the RECoVERED Study Group |
| author_sort | Anouk Verveen |
| collection | DOAJ |
| description | Abstract Background Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization. We compared HRQL among persons with initial mild, moderate or severe/critical COVID-19 at 1 and 12 months following illness onset with Dutch population norms and investigated the impact of restrictive public health control measures on HRQL. Methods RECoVERED, a prospective cohort study in Amsterdam, the Netherlands, enrolled adult participants after confirmed SARS-CoV-2 diagnosis. HRQL was assessed with the Medical Outcomes Study Short Form 36-item health survey (SF-36). SF-36 scores were converted to standard scores based on an age- and sex-matched representative reference sample of the Dutch population. Differences in HRQL over time were compared among persons with initial mild, moderate or severe/critical COVID-19 using mixed linear models adjusted for potential confounders. Results By December 2021, 349 persons were enrolled of whom 269 completed at least one SF-36 form (77%). One month after illness onset, HRQL was significantly below population norms on all SF-36 domains except general health and bodily pain among persons with mild COVID-19. After 12 months, persons with mild COVID-19 had HRQL within population norms, whereas persons with moderate or severe/critical COVID-19 had HRQL below population norms on more than half of the SF-36 domains. Dutch-origin participants had significantly better HRQL than participants with a migration background. Participants with three or more COVID-19 high-risk comorbidities had worse HRQL than part participants with fewer comorbidities. Participants who completed the SF-36 when restrictive public health control measures applied reported less limitations in social and physical functioning and less impaired mental health than participants who completed the SF-36 when no restrictive measures applied. Conclusions Twelve months after illness onset, persons with initial mild COVID-19 had HRQL within population norms, whereas persons with initial moderate or severe/critical COVID-19 still had impaired HRQL. Having a migration background and a higher number of COVID-19 high-risk comorbidities were associated with worse HRQL. Interestingly, HRQL was less impaired during periods when restrictive public health control measures were in place compared to periods without. |
| first_indexed | 2024-04-11T07:05:49Z |
| format | Article |
| id | doaj.art-7b4ecab72e074b5aadc2a683ed8f68c3 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-04-11T07:05:49Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-7b4ecab72e074b5aadc2a683ed8f68c32022-12-22T04:38:23ZengBMCBMC Medicine1741-70152022-11-0120111210.1186/s12916-022-02615-7Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort studyAnouk Verveen0Elke Wynberg1Hugo D. G. van Willigen2Udi Davidovich3Anja Lok4Eric P. Moll van Charante5Menno D. de Jong6Godelieve de Bree7Maria Prins8Hans Knoop9Pythia T. Nieuwkerk10the RECoVERED Study GroupDepartment of Medical Psychology (J3-2019-1), Amsterdam UMC location AMC University of AmsterdamDepartment of Infectious Diseases, Public Health Service of AmsterdamDepartment of Infectious Diseases, Amsterdam UMC location University of AmsterdamDepartment of Infectious Diseases, Public Health Service of AmsterdamAmsterdam Public HealthAmsterdam Public HealthAmsterdam Institute for Infection and Immunity, Infectious DiseasesDepartment of Infectious Diseases, Amsterdam UMC location University of AmsterdamDepartment of Infectious Diseases, Public Health Service of AmsterdamDepartment of Medical Psychology (J3-2019-1), Amsterdam UMC location AMC University of AmsterdamDepartment of Medical Psychology (J3-2019-1), Amsterdam UMC location AMC University of AmsterdamAbstract Background Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization. We compared HRQL among persons with initial mild, moderate or severe/critical COVID-19 at 1 and 12 months following illness onset with Dutch population norms and investigated the impact of restrictive public health control measures on HRQL. Methods RECoVERED, a prospective cohort study in Amsterdam, the Netherlands, enrolled adult participants after confirmed SARS-CoV-2 diagnosis. HRQL was assessed with the Medical Outcomes Study Short Form 36-item health survey (SF-36). SF-36 scores were converted to standard scores based on an age- and sex-matched representative reference sample of the Dutch population. Differences in HRQL over time were compared among persons with initial mild, moderate or severe/critical COVID-19 using mixed linear models adjusted for potential confounders. Results By December 2021, 349 persons were enrolled of whom 269 completed at least one SF-36 form (77%). One month after illness onset, HRQL was significantly below population norms on all SF-36 domains except general health and bodily pain among persons with mild COVID-19. After 12 months, persons with mild COVID-19 had HRQL within population norms, whereas persons with moderate or severe/critical COVID-19 had HRQL below population norms on more than half of the SF-36 domains. Dutch-origin participants had significantly better HRQL than participants with a migration background. Participants with three or more COVID-19 high-risk comorbidities had worse HRQL than part participants with fewer comorbidities. Participants who completed the SF-36 when restrictive public health control measures applied reported less limitations in social and physical functioning and less impaired mental health than participants who completed the SF-36 when no restrictive measures applied. Conclusions Twelve months after illness onset, persons with initial mild COVID-19 had HRQL within population norms, whereas persons with initial moderate or severe/critical COVID-19 still had impaired HRQL. Having a migration background and a higher number of COVID-19 high-risk comorbidities were associated with worse HRQL. Interestingly, HRQL was less impaired during periods when restrictive public health control measures were in place compared to periods without.https://doi.org/10.1186/s12916-022-02615-7SARS-CoV-2COVID-19Quality of lifeHealth-related quality of life |
| spellingShingle | Anouk Verveen Elke Wynberg Hugo D. G. van Willigen Udi Davidovich Anja Lok Eric P. Moll van Charante Menno D. de Jong Godelieve de Bree Maria Prins Hans Knoop Pythia T. Nieuwkerk the RECoVERED Study Group Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study BMC Medicine SARS-CoV-2 COVID-19 Quality of life Health-related quality of life |
| title | Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study |
| title_full | Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study |
| title_fullStr | Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study |
| title_full_unstemmed | Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study |
| title_short | Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study |
| title_sort | health related quality of life among persons with initial mild moderate and severe or critical covid 19 at 1 and 12 months after infection a prospective cohort study |
| topic | SARS-CoV-2 COVID-19 Quality of life Health-related quality of life |
| url | https://doi.org/10.1186/s12916-022-02615-7 |
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