Levetiracetam attenuates diabetes-associated cognitive impairment and microglia polarization by suppressing neuroinflammation

Levetiracetam attenuates diabetes-associated cognitive impairment and microglia polarization by suppressing neuroinflammation

Introduction: Cognitive impairment is a common complication and comorbidity of diabetes. However, the underlying mechanisms of diabetes-associated cognitive dysfunction are currently unclear. M1 microglia secretes pro-inflammatory factors and can be marked by CD16, iNOS, Iba1 and TNF-ɑ. The decline...

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Bibliographic Details
Main Authors: Yun-yun Zhang, Lu Wang, Hua Guo, Ting-ting Han, Yan-hua Chang, Xiao-chuan Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
diabetic
cognition
levetiracetam
microglia polarization
JNK/MAPK/ NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1145819/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1145819/full

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