Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression
Stilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory...
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/3677 |
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| author | João C. Fernandes Elizângela G. Schemitt Juliana Da Silva Norma P. Marroni Ana Lima Ricardo B. Ferreira |
| author_facet | João C. Fernandes Elizângela G. Schemitt Juliana Da Silva Norma P. Marroni Ana Lima Ricardo B. Ferreira |
| author_sort | João C. Fernandes |
| collection | DOAJ |
| description | Stilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory development an in vivo model of severe acute liver failure induced with TAA. Trans-resveratrol + trans-ε-viniferin (5 mg/kg each) was administered to Wistar rats. Resveratrol + ε-viniferin significantly decreased TBARS and SOD activity and restored CAT and GST activities in the treated group. This stilbene combination reduced the expression of TNFα, iNOS, and COX-2, and inhibited MMP-9. The combination of resveratrol + ε-viniferin had a hepatoprotective effect, reducing DNA damage, exhibiting a protective role on the antioxidant pathway by altering SOD, CAT, and GST activities; by downregulating TNFα, COX-2, and iNOS; and upregulating IL-10. Our results suggested that adding viniferin to resveratrol may be more effective in hepatoprotection than resveratrol alone, opening a new perspective on using this stilbene combination in functional diets. |
| first_indexed | 2024-03-10T05:11:57Z |
| format | Article |
| id | doaj.art-7b529d76ec1e494d89e6b071e9dd8af6 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T05:11:57Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-7b529d76ec1e494d89e6b071e9dd8af62023-11-23T00:44:12ZengMDPI AGNutrients2072-66432021-10-011311367710.3390/nu13113677Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 ExpressionJoão C. Fernandes0Elizângela G. Schemitt1Juliana Da Silva2Norma P. Marroni3Ana Lima4Ricardo B. Ferreira5Linking Landscape, Environment, Agriculture and Food (LEAF), Universidade de Lisboa, Instituto Superior de Agronomia, Tapada da Ajuda, 1349-017 Lisbon, PortugalLaboratory of Experimental Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90040-060, BrazilLaboratório de Genética Toxicológica, Universidade Luterana do Brasil, Canoas 92425-900, BrazilLaboratory of Experimental Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90040-060, BrazilLinking Landscape, Environment, Agriculture and Food (LEAF), Universidade de Lisboa, Instituto Superior de Agronomia, Tapada da Ajuda, 1349-017 Lisbon, PortugalLinking Landscape, Environment, Agriculture and Food (LEAF), Universidade de Lisboa, Instituto Superior de Agronomia, Tapada da Ajuda, 1349-017 Lisbon, PortugalStilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory development an in vivo model of severe acute liver failure induced with TAA. Trans-resveratrol + trans-ε-viniferin (5 mg/kg each) was administered to Wistar rats. Resveratrol + ε-viniferin significantly decreased TBARS and SOD activity and restored CAT and GST activities in the treated group. This stilbene combination reduced the expression of TNFα, iNOS, and COX-2, and inhibited MMP-9. The combination of resveratrol + ε-viniferin had a hepatoprotective effect, reducing DNA damage, exhibiting a protective role on the antioxidant pathway by altering SOD, CAT, and GST activities; by downregulating TNFα, COX-2, and iNOS; and upregulating IL-10. Our results suggested that adding viniferin to resveratrol may be more effective in hepatoprotection than resveratrol alone, opening a new perspective on using this stilbene combination in functional diets.https://www.mdpi.com/2072-6643/13/11/3677inflammationliver failureMMP-9oxidative stressresveratrolstilbenes |
| spellingShingle | João C. Fernandes Elizângela G. Schemitt Juliana Da Silva Norma P. Marroni Ana Lima Ricardo B. Ferreira Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression Nutrients inflammation liver failure MMP-9 oxidative stress resveratrol stilbenes |
| title | Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression |
| title_full | Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression |
| title_fullStr | Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression |
| title_full_unstemmed | Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression |
| title_short | Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression |
| title_sort | combination of trans resveratrol and ε viniferin induces a hepatoprotective effect in rats with severe acute liver failure via reduction of oxidative stress and mmp 9 expression |
| topic | inflammation liver failure MMP-9 oxidative stress resveratrol stilbenes |
| url | https://www.mdpi.com/2072-6643/13/11/3677 |
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