EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear. Here, the authors show that coupling between EpCAM/RhoA co-trafficking and actomyosin rearrangement is pivotal during cell spreadi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22482-9 |
| _version_ | 1818435135939280896 |
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| author | Cécile Gaston Simon De Beco Bryant Doss Meng Pan Estelle Gauquelin Joseph D’Alessandro Chwee Teck Lim Benoit Ladoux Delphine Delacour |
| author_facet | Cécile Gaston Simon De Beco Bryant Doss Meng Pan Estelle Gauquelin Joseph D’Alessandro Chwee Teck Lim Benoit Ladoux Delphine Delacour |
| author_sort | Cécile Gaston |
| collection | DOAJ |
| description | The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear. Here, the authors show that coupling between EpCAM/RhoA co-trafficking and actomyosin rearrangement is pivotal during cell spreading and polarization. |
| first_indexed | 2024-12-14T16:48:05Z |
| format | Article |
| id | doaj.art-7b55341483d34cfa93325ca1970195c7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:48:05Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7b55341483d34cfa93325ca1970195c72022-12-21T22:54:07ZengNature PortfolioNature Communications2041-17232021-04-0112112210.1038/s41467-021-22482-9EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organizationCécile Gaston0Simon De Beco1Bryant Doss2Meng Pan3Estelle Gauquelin4Joseph D’Alessandro5Chwee Teck Lim6Benoit Ladoux7Delphine Delacour8Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot UniversityCell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot UniversityMechanobiology Institute, T-labMechanobiology Institute, T-labCell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot UniversityCell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot UniversityMechanobiology Institute, T-labCell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot UniversityCell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot UniversityThe organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear. Here, the authors show that coupling between EpCAM/RhoA co-trafficking and actomyosin rearrangement is pivotal during cell spreading and polarization.https://doi.org/10.1038/s41467-021-22482-9 |
| spellingShingle | Cécile Gaston Simon De Beco Bryant Doss Meng Pan Estelle Gauquelin Joseph D’Alessandro Chwee Teck Lim Benoit Ladoux Delphine Delacour EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization Nature Communications |
| title | EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization |
| title_full | EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization |
| title_fullStr | EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization |
| title_full_unstemmed | EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization |
| title_short | EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization |
| title_sort | epcam promotes endosomal modulation of the cortical rhoa zone for epithelial organization |
| url | https://doi.org/10.1038/s41467-021-22482-9 |
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