Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis
IntroductionPolypharmacy and potentially inappropriate medication use is common in older adults and is associated with adverse outcomes such as falls and hospitalisations.Methods and analysisThis study is a pharmacist-led medication optimisation initiative using an electronic tool (the Drug Burden I...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/2/e035656.full |
| _version_ | 1819149038178533376 |
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| author | Kenneth Rockwood Sarah Hilmer Emily Reeve Mohammad Hajizadeh Marci Elizabeth Dearing Susan Bowles Jennifer Isenor Olga Kits Lisa Kouladjian O'Donnell Heather Neville Kent Toombs Caroline Sirois Aprill Negus |
| author_facet | Kenneth Rockwood Sarah Hilmer Emily Reeve Mohammad Hajizadeh Marci Elizabeth Dearing Susan Bowles Jennifer Isenor Olga Kits Lisa Kouladjian O'Donnell Heather Neville Kent Toombs Caroline Sirois Aprill Negus |
| author_sort | Kenneth Rockwood |
| collection | DOAJ |
| description | IntroductionPolypharmacy and potentially inappropriate medication use is common in older adults and is associated with adverse outcomes such as falls and hospitalisations.Methods and analysisThis study is a pharmacist-led medication optimisation initiative using an electronic tool (the Drug Burden Index (DBI) Calculator) in four hospital sites in the Canadian province of Nova Scotia. The study aims to enrol 160 participants between the preintervention and intervention groups. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT 2013 checklist) was used to develop the protocol for this prospective interventional implementation study. A preintervention retrospective control cohort and a multiple case study analysis will also be used to assess the effect of intervention implementation. Statistical analysis will involve change in DBI scores and assessment of clinical outcomes, such as rehospitalisation and mortality using appropriate statistical tests including t-test, χ2, analysis of variance and unadjusted and adjusted regression methods.Ethics and disseminationEthics approval has been granted by the Nova Scotia Health Authority Research Ethics Board. The findings of this study will be published in peer-reviewed journals and presented at local, national and international conferences.Trial registration numberNCT03698487. |
| first_indexed | 2024-12-22T13:55:15Z |
| format | Article |
| id | doaj.art-7b5693faa51e41f9aef2baeb5662c72c |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-12-22T13:55:15Z |
| publishDate | 2020-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-7b5693faa51e41f9aef2baeb5662c72c2022-12-21T18:23:34ZengBMJ Publishing GroupBMJ Open2044-60552020-02-0110210.1136/bmjopen-2019-035656Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysisKenneth Rockwood0Sarah Hilmer1Emily Reeve2Mohammad Hajizadeh3Marci Elizabeth Dearing4Susan Bowles5Jennifer Isenor6Olga Kits7Lisa Kouladjian O'Donnell8Heather Neville9Kent Toombs10Caroline Sirois11Aprill Negus125 Dalhousie University, Halifax, Nova Scotia, Canada 3 Department of Clinical Pharmacology and Aged Care, Kolling Institute of Medical Research, Royal North Shore Hospital School, Saint Leonards, New South Wales, Australia 9 Quality Use of Medicines and Pharmacy Research Centre, School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia School of Health Administration, Dalhousie University, Halifax, Nova Scotia, CanadaGeriatric Medicine Research, Nova Scotia Health Authority, Halifax, Nova Scotia, CanadaDepartment of Pharmacy, Nova Scotia Health Authority, Halifax, Nova Scotia, CanadaCollege of Pharmacy, Dalhousie University, Halifax, Nova Scotia, CanadaResearch Methods Unit, Nova Scotia Health Authority, Halifax, Nova Scotia, CanadaNHMRC Cognitive Decline Partnership Centre, Kolling Institute of Medical Research, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaDepartment of Pharmacy, Nova Scotia Health Authority, Halifax, Nova Scotia, CanadaDepartment of Pharmacy, Nova Scotia Health Authority, Halifax, Nova Scotia, CanadaDepartment of Social and Preventive Medicine, Faculty of Medicine, Universite Laval, Québec city, Quebec, CanadaDepartment of Family Medicine, Nova Scotia Health Authority, Halifax, Nova Scotia, CanadaIntroductionPolypharmacy and potentially inappropriate medication use is common in older adults and is associated with adverse outcomes such as falls and hospitalisations.Methods and analysisThis study is a pharmacist-led medication optimisation initiative using an electronic tool (the Drug Burden Index (DBI) Calculator) in four hospital sites in the Canadian province of Nova Scotia. The study aims to enrol 160 participants between the preintervention and intervention groups. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT 2013 checklist) was used to develop the protocol for this prospective interventional implementation study. A preintervention retrospective control cohort and a multiple case study analysis will also be used to assess the effect of intervention implementation. Statistical analysis will involve change in DBI scores and assessment of clinical outcomes, such as rehospitalisation and mortality using appropriate statistical tests including t-test, χ2, analysis of variance and unadjusted and adjusted regression methods.Ethics and disseminationEthics approval has been granted by the Nova Scotia Health Authority Research Ethics Board. The findings of this study will be published in peer-reviewed journals and presented at local, national and international conferences.Trial registration numberNCT03698487.https://bmjopen.bmj.com/content/10/2/e035656.full |
| spellingShingle | Kenneth Rockwood Sarah Hilmer Emily Reeve Mohammad Hajizadeh Marci Elizabeth Dearing Susan Bowles Jennifer Isenor Olga Kits Lisa Kouladjian O'Donnell Heather Neville Kent Toombs Caroline Sirois Aprill Negus Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis BMJ Open |
| title | Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis |
| title_full | Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis |
| title_fullStr | Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis |
| title_full_unstemmed | Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis |
| title_short | Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis |
| title_sort | pharmacist led intervention to improve medication use in older inpatients using the drug burden index a study protocol for a before after intervention with a retrospective control group and multiple case analysis |
| url | https://bmjopen.bmj.com/content/10/2/e035656.full |
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