Lessons from the Endoplasmic Reticulum Ca<sup>2+</sup> Transporters—A Cancer Connection
Ca<sup>2+</sup> is an integral mediator of intracellular signaling, impacting almost every aspect of cellular life. The Ca<sup>2+</sup>-conducting transporters located on the endoplasmic reticulum (ER) membrane shoulder the responsibility of constructing the global Ca<sup&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1536 |
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| author | Xingjian Zhai Andra Mihaela Sterea Yassine El Hiani |
| author_facet | Xingjian Zhai Andra Mihaela Sterea Yassine El Hiani |
| author_sort | Xingjian Zhai |
| collection | DOAJ |
| description | Ca<sup>2+</sup> is an integral mediator of intracellular signaling, impacting almost every aspect of cellular life. The Ca<sup>2+</sup>-conducting transporters located on the endoplasmic reticulum (ER) membrane shoulder the responsibility of constructing the global Ca<sup>2+</sup> signaling landscape. These transporters gate the ER Ca<sup>2+</sup> release and uptake, sculpt signaling duration and intensity, and compose the Ca<sup>2+</sup> signaling rhythm to accommodate a plethora of biological activities. In this review, we explore the mechanisms of activation and functional regulation of ER Ca<sup>2+</sup> transporters in the establishment of Ca<sup>2+</sup> homeostasis. We also contextualize the aberrant alterations of these transporters in carcinogenesis, presenting Ca<sup>2+</sup>-based therapeutic interventions as a means to tackle malignancies. |
| first_indexed | 2024-03-10T18:55:23Z |
| format | Article |
| id | doaj.art-7b57aab89e704cae86b1c747081c4d56 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T18:55:23Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7b57aab89e704cae86b1c747081c4d562023-11-20T04:49:30ZengMDPI AGCells2073-44092020-06-0196153610.3390/cells9061536Lessons from the Endoplasmic Reticulum Ca<sup>2+</sup> Transporters—A Cancer ConnectionXingjian Zhai0Andra Mihaela Sterea1Yassine El Hiani2Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, CanadaFaculty of Dentistry, Dalhousie University, Halifax, NS B3H 4R2, CanadaDepartment of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, CanadaCa<sup>2+</sup> is an integral mediator of intracellular signaling, impacting almost every aspect of cellular life. The Ca<sup>2+</sup>-conducting transporters located on the endoplasmic reticulum (ER) membrane shoulder the responsibility of constructing the global Ca<sup>2+</sup> signaling landscape. These transporters gate the ER Ca<sup>2+</sup> release and uptake, sculpt signaling duration and intensity, and compose the Ca<sup>2+</sup> signaling rhythm to accommodate a plethora of biological activities. In this review, we explore the mechanisms of activation and functional regulation of ER Ca<sup>2+</sup> transporters in the establishment of Ca<sup>2+</sup> homeostasis. We also contextualize the aberrant alterations of these transporters in carcinogenesis, presenting Ca<sup>2+</sup>-based therapeutic interventions as a means to tackle malignancies.https://www.mdpi.com/2073-4409/9/6/1536endoplasmic reticulumcalciumIP<sub>3</sub>RRyRSERCASTIM/Orai |
| spellingShingle | Xingjian Zhai Andra Mihaela Sterea Yassine El Hiani Lessons from the Endoplasmic Reticulum Ca<sup>2+</sup> Transporters—A Cancer Connection Cells endoplasmic reticulum calcium IP<sub>3</sub>R RyR SERCA STIM/Orai |
| title | Lessons from the Endoplasmic Reticulum Ca<sup>2+</sup> Transporters—A Cancer Connection |
| title_full | Lessons from the Endoplasmic Reticulum Ca<sup>2+</sup> Transporters—A Cancer Connection |
| title_fullStr | Lessons from the Endoplasmic Reticulum Ca<sup>2+</sup> Transporters—A Cancer Connection |
| title_full_unstemmed | Lessons from the Endoplasmic Reticulum Ca<sup>2+</sup> Transporters—A Cancer Connection |
| title_short | Lessons from the Endoplasmic Reticulum Ca<sup>2+</sup> Transporters—A Cancer Connection |
| title_sort | lessons from the endoplasmic reticulum ca sup 2 sup transporters a cancer connection |
| topic | endoplasmic reticulum calcium IP<sub>3</sub>R RyR SERCA STIM/Orai |
| url | https://www.mdpi.com/2073-4409/9/6/1536 |
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