Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised mice
Equol is a metabolite of the isoflavone daidzein (Dz) and is produced by the bacterial microflora in the distal intestine and colon. Some epidemiological studies have reported an association between increased equol production and intakes of green tea or dietary fibre, which are ingredients of the st...
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| Format: | Article |
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Cambridge University Press
2012-10-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679012000146/type/journal_article |
| _version_ | 1811155997767499776 |
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| author | Yuko Tousen Mariko Uehara Marlena Cathorina Kruger Yoshiko Ishimi |
| author_facet | Yuko Tousen Mariko Uehara Marlena Cathorina Kruger Yoshiko Ishimi |
| author_sort | Yuko Tousen |
| collection | DOAJ |
| description | Equol is a metabolite of the isoflavone daidzein (Dz) and is produced by the bacterial microflora in the distal intestine and colon. Some epidemiological studies have reported an association between increased equol production and intakes of green tea or dietary fibre, which are ingredients of the standard Japanese diet. We examined the effects of a diet supplemented with Dz and tea catechin or dietary fibre on equol production and bone mineral density in ovariectomised (OVX) mice. Female mice of the ddY strain were either sham operated or OVX. OVX mice were fed a control diet, a 0·1 % Dz-supplemented diet or a 0·1 % Dz diet supplemented with one of the food components commonly consumed in the Japanese diet. The mice were given 1 % tea catechin (w/w) as part of the diet in Expt 1 or 5 % polydextrose (PD) and 5 % raffinose (Raf) (w/w) as part of the diet in Expt 2. Catechin reduced serum equol levels and attenuated the beneficial effect of Dz on femoral bone loss. The soluble dietary fibres PD and Raf stimulated equol production, and enhanced the bone-protective effects of Dz on femoral bone. These results suggest that dietary fibre, in particular, PD, may alter the bioavailability of isoflavones and prevent osteopenia in OVX mice. |
| first_indexed | 2024-04-10T04:44:03Z |
| format | Article |
| id | doaj.art-7b5a07fdbe83405b8bba699b4dd0f683 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:44:03Z |
| publishDate | 2012-10-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-7b5a07fdbe83405b8bba699b4dd0f6832023-03-09T12:38:30ZengCambridge University PressJournal of Nutritional Science2048-67902012-10-01110.1017/jns.2012.14Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised miceYuko Tousen0Mariko Uehara1Marlena Cathorina Kruger2Yoshiko Ishimi3Department of Food Function and Labeling, National Institute of Health and Nutrition, Tokyo, Japan Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New ZealandDepartment of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, JapanInstitute of Food, Nutrition and Human Health, Massey University, Palmerston North, New ZealandDepartment of Food Function and Labeling, National Institute of Health and Nutrition, Tokyo, JapanEquol is a metabolite of the isoflavone daidzein (Dz) and is produced by the bacterial microflora in the distal intestine and colon. Some epidemiological studies have reported an association between increased equol production and intakes of green tea or dietary fibre, which are ingredients of the standard Japanese diet. We examined the effects of a diet supplemented with Dz and tea catechin or dietary fibre on equol production and bone mineral density in ovariectomised (OVX) mice. Female mice of the ddY strain were either sham operated or OVX. OVX mice were fed a control diet, a 0·1 % Dz-supplemented diet or a 0·1 % Dz diet supplemented with one of the food components commonly consumed in the Japanese diet. The mice were given 1 % tea catechin (w/w) as part of the diet in Expt 1 or 5 % polydextrose (PD) and 5 % raffinose (Raf) (w/w) as part of the diet in Expt 2. Catechin reduced serum equol levels and attenuated the beneficial effect of Dz on femoral bone loss. The soluble dietary fibres PD and Raf stimulated equol production, and enhanced the bone-protective effects of Dz on femoral bone. These results suggest that dietary fibre, in particular, PD, may alter the bioavailability of isoflavones and prevent osteopenia in OVX mice.https://www.cambridge.org/core/product/identifier/S2048679012000146/type/journal_articleSoya isoflavonesEquolJapanese dietDietary fibre |
| spellingShingle | Yuko Tousen Mariko Uehara Marlena Cathorina Kruger Yoshiko Ishimi Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised mice Journal of Nutritional Science Soya isoflavones Equol Japanese diet Dietary fibre |
| title | Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised mice |
| title_full | Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised mice |
| title_fullStr | Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised mice |
| title_full_unstemmed | Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised mice |
| title_short | Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised mice |
| title_sort | effects of dietary fibre and tea catechin ingredients of the japanese diet on equol production and bone mineral density in isoflavone treated ovariectomised mice |
| topic | Soya isoflavones Equol Japanese diet Dietary fibre |
| url | https://www.cambridge.org/core/product/identifier/S2048679012000146/type/journal_article |
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