Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae
Raturi and Nair et al. describe functional ion pathways within the MATE transporter NorM from Vibrio cholerae (NorM-VC). By creating chimeric proteins and mutants of NorM-VC and NorM-PS, they dissect the localisation of ion-coupling events and roles of conserved catalytic carboxylates in H+ binding...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02081-6 |