Evaluating the local expression pattern of IGF-1R in tumor tissues and the circulating levels of IGF-1, IGFBP-1, and IGFBP-3 in the blood of patients with different primary bone tumors

Evaluating the local expression pattern of IGF-1R in tumor tissues and the circulating levels of IGF-1, IGFBP-1, and IGFBP-3 in the blood of patients with different primary bone tumors

IntroductionThe present study tried to provide insights into the expression pattern and diagnostic significance of the IGF-1 axis main mediators in three main primary bone tumor types with different degrees of severity.MethodsThe real-time qRT-PCR (to analyze IGF-1R gene expression), the immunohisto...

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Bibliographic Details
Main Authors: Mohammad Amin Vaezi, Amir Reza Eghtedari, Banafsheh Safizadeh, Pegah Babaheidarian, Vahid Salimi, Fatemeh Adjaminezhad-Fard, Sahar Yarahmadi, Alireza Mirzaei, Mahtab Rahbar, Masoumeh Tavakoli-Yaraki
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
insulin-like growth factor-1 (IGF-1)
bone tumors
osteosarcoma
Ewing sarcoma
giant cell tumors
tumor recurrence
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1096438/full

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