Testicular Neoplasms: Primary Tumour Size Is Closely Interrelated with Histology, Clinical Staging, and Tumour Marker Expression Rates—A Comprehensive Statistical Analysis
The role of primary tumour size (TS) in the clinical course of testicular tumours is incompletely understood. We retrospectively evaluated 641 consecutive patients with testicular neoplasms with regard to TS, histology, clinical stage (CS), serum tumour marker (STM) expression and patient age using...
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MDPI AG
2022-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/21/5447 |
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| author | Klaus-Peter Dieckmann Hendrik Isbarn Francesca Grobelny Cansu Dumlupinar Julia Utschig Christian Wülfing Uwe Pichlmeier Gazanfer Belge |
| author_facet | Klaus-Peter Dieckmann Hendrik Isbarn Francesca Grobelny Cansu Dumlupinar Julia Utschig Christian Wülfing Uwe Pichlmeier Gazanfer Belge |
| author_sort | Klaus-Peter Dieckmann |
| collection | DOAJ |
| description | The role of primary tumour size (TS) in the clinical course of testicular tumours is incompletely understood. We retrospectively evaluated 641 consecutive patients with testicular neoplasms with regard to TS, histology, clinical stage (CS), serum tumour marker (STM) expression and patient age using descriptive statistical methods. TS ≤ 10 mm was encountered in 13.6% of cases. Median TS of 10 mm, 30 mm, 35 mm, and 53 mm were found in benign tumours, seminomas, nonseminomas, and other malignant tumours, respectively. In cases with TS ≤ 10 mm, 50.6% had benign tumours. Upon receiver operating characteristics analysis, TS of > 16 mm revealed 81.5% sensitivity and 81.0% specificity for detecting malignancy. In subcentimeter germ cell tumours (GCTs), 97.7% of cases had CS1, and CS1 frequency dropped with increasing TS. Expression rates of all STMs significantly increased with TS. MicroRNA-371a-3p (M371) serum levels had higher expression rates than classical STMs, with a rate of 44.1% in subcentimeter GCTs. In all, TS is a biologically relevant factor owing to its significant associations with CS, STM expression rates and histology. Importantly, 50% of subcentimeter testicular neoplasms are of benign nature, and M371 outperforms the classical markers even in subcentimeter tumours. |
| first_indexed | 2024-03-09T19:12:19Z |
| format | Article |
| id | doaj.art-7b60c28e0f2b4e06b97d584509717e6a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T19:12:19Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7b60c28e0f2b4e06b97d584509717e6a2023-11-24T04:04:34ZengMDPI AGCancers2072-66942022-11-011421544710.3390/cancers14215447Testicular Neoplasms: Primary Tumour Size Is Closely Interrelated with Histology, Clinical Staging, and Tumour Marker Expression Rates—A Comprehensive Statistical AnalysisKlaus-Peter Dieckmann0Hendrik Isbarn1Francesca Grobelny2Cansu Dumlupinar3Julia Utschig4Christian Wülfing5Uwe Pichlmeier6Gazanfer Belge7Department of Urology, Asklepios Klinik Altona, D-22763 Hamburg, GermanyMartini Klinik, Universitätsklinikum Eppendorf, Martinistrasse 52, D-20251 Hamburg, GermanyTumour Genetics Department, Faculty of Biology and Chemistry, Tumour Genetics, University of Bremen, Leobener Strasse 2/FVG, 28359 Bremen, GermanyTumour Genetics Department, Faculty of Biology and Chemistry, Tumour Genetics, University of Bremen, Leobener Strasse 2/FVG, 28359 Bremen, GermanyDepartment of Urology, Asklepios Klinik Altona, D-22763 Hamburg, GermanyDepartment of Urology, Asklepios Klinik Altona, D-22763 Hamburg, GermanyInstitute of Medical Biometry und Epidemiology, Universitätsklinikum Eppendorf, Martinistrasse 52, D-20251 Hamburg, GermanyTumour Genetics Department, Faculty of Biology and Chemistry, Tumour Genetics, University of Bremen, Leobener Strasse 2/FVG, 28359 Bremen, GermanyThe role of primary tumour size (TS) in the clinical course of testicular tumours is incompletely understood. We retrospectively evaluated 641 consecutive patients with testicular neoplasms with regard to TS, histology, clinical stage (CS), serum tumour marker (STM) expression and patient age using descriptive statistical methods. TS ≤ 10 mm was encountered in 13.6% of cases. Median TS of 10 mm, 30 mm, 35 mm, and 53 mm were found in benign tumours, seminomas, nonseminomas, and other malignant tumours, respectively. In cases with TS ≤ 10 mm, 50.6% had benign tumours. Upon receiver operating characteristics analysis, TS of > 16 mm revealed 81.5% sensitivity and 81.0% specificity for detecting malignancy. In subcentimeter germ cell tumours (GCTs), 97.7% of cases had CS1, and CS1 frequency dropped with increasing TS. Expression rates of all STMs significantly increased with TS. MicroRNA-371a-3p (M371) serum levels had higher expression rates than classical STMs, with a rate of 44.1% in subcentimeter GCTs. In all, TS is a biologically relevant factor owing to its significant associations with CS, STM expression rates and histology. Importantly, 50% of subcentimeter testicular neoplasms are of benign nature, and M371 outperforms the classical markers even in subcentimeter tumours.https://www.mdpi.com/2072-6694/14/21/5447testicular tumourseminomatumour markermicroRNAtumour sizegerm cell tumour |
| spellingShingle | Klaus-Peter Dieckmann Hendrik Isbarn Francesca Grobelny Cansu Dumlupinar Julia Utschig Christian Wülfing Uwe Pichlmeier Gazanfer Belge Testicular Neoplasms: Primary Tumour Size Is Closely Interrelated with Histology, Clinical Staging, and Tumour Marker Expression Rates—A Comprehensive Statistical Analysis Cancers testicular tumour seminoma tumour marker microRNA tumour size germ cell tumour |
| title | Testicular Neoplasms: Primary Tumour Size Is Closely Interrelated with Histology, Clinical Staging, and Tumour Marker Expression Rates—A Comprehensive Statistical Analysis |
| title_full | Testicular Neoplasms: Primary Tumour Size Is Closely Interrelated with Histology, Clinical Staging, and Tumour Marker Expression Rates—A Comprehensive Statistical Analysis |
| title_fullStr | Testicular Neoplasms: Primary Tumour Size Is Closely Interrelated with Histology, Clinical Staging, and Tumour Marker Expression Rates—A Comprehensive Statistical Analysis |
| title_full_unstemmed | Testicular Neoplasms: Primary Tumour Size Is Closely Interrelated with Histology, Clinical Staging, and Tumour Marker Expression Rates—A Comprehensive Statistical Analysis |
| title_short | Testicular Neoplasms: Primary Tumour Size Is Closely Interrelated with Histology, Clinical Staging, and Tumour Marker Expression Rates—A Comprehensive Statistical Analysis |
| title_sort | testicular neoplasms primary tumour size is closely interrelated with histology clinical staging and tumour marker expression rates a comprehensive statistical analysis |
| topic | testicular tumour seminoma tumour marker microRNA tumour size germ cell tumour |
| url | https://www.mdpi.com/2072-6694/14/21/5447 |
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