Predicting disordered regions driving phase separation of proteins under variable salt concentration

Predicting disordered regions driving phase separation of proteins under variable salt concentration

We investigate intrinsically disordered regions (IDRs) of phase separating proteins regarding their impact on liquid-liquid phase separation (LLPS) of the full protein. Our theoretical approach uses a mean-field theory that accounts for sequence-dependent electrostatic interactions via a Random Phas...

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Bibliographic Details
Main Authors:	Esteban Meca, Anatol W. Fritsch, Juan M. Iglesias-Artola, Simone Reber, Barbara Wagner
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Physics
Subjects:	intrinsically disordered proteins (IDP) Random Phase Approximation (RPA) FUS liquid-liquid phase separation (LLPS) phase diagrams
Online Access:	https://www.frontiersin.org/articles/10.3389/fphy.2023.1213304/full

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