Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity
Background: Recent research has identified a general psychopathology factor (GPF), which explains overlap in presentation of psychopathological symptoms. Unresolved–disorganized attachment (Ud) is another transdiagnostic risk factor that may be relevant to explain differences in patient characterist...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-12-01
|
| Series: | European Journal of Psychotraumatology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20008198.2019.1583525 |
| _version_ | 1797954597492359168 |
|---|---|
| author | Marie-José van Hoof Madelon M. E. Riem Amy S. Garrett Nic J. A. van der Wee Marinus H. van IJzendoorn Robert R. J. M Vermeiren |
| author_facet | Marie-José van Hoof Madelon M. E. Riem Amy S. Garrett Nic J. A. van der Wee Marinus H. van IJzendoorn Robert R. J. M Vermeiren |
| author_sort | Marie-José van Hoof |
| collection | DOAJ |
| description | Background: Recent research has identified a general psychopathology factor (GPF), which explains overlap in presentation of psychopathological symptoms. Unresolved–disorganized attachment (Ud) is another transdiagnostic risk factor that may be relevant to explain differences in patient characteristics within diagnostic classifications. Objective: In the current study, we examined unique relations of resting-state functional connectivity (RSFC) with Ud and GPF. Method: RSFC data were collected from a mixed group of adolescents (N = 74) with and without psychiatric disorder, as part of the Emotional Pathways’ Imaging Study in Clinical Adolescents (EPISCA) study. Ud was measured using the Adult Attachment Interview (AAI). Associations between Ud, GPF, and RSFC of the amygdala and dorsal anterior cingulate cortex (dACC) and with amygdala–medial frontal connectivity were examined. Results: Ud was positively associated with greater functional connectivity between the left amygdala and the left lateral occipital cortex, precuneus, and superior parietal lobule. Furthermore, Ud was negatively associated with left amygdala–medial frontal cortex connectivity. GPF was not significantly associated with dACC or amygdala connectivity. Conclusions: Atypical amygdala connectivity may reflect a vulnerability factor rather than a biomarker of psychopathology. The unique association of Ud and amygdala RSFC, adjusted for a GPF, across participants with and without various classifications of psychopathology illustrates that dimensional approaches based on the AAI may complement psychiatric classifications in clinical research and practice. |
| first_indexed | 2024-04-10T23:19:54Z |
| format | Article |
| id | doaj.art-7b62142375674fbe8323ff24be910080 |
| institution | Directory Open Access Journal |
| issn | 2000-8066 |
| language | English |
| last_indexed | 2024-04-10T23:19:54Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Journal of Psychotraumatology |
| spelling | doaj.art-7b62142375674fbe8323ff24be9100802023-01-12T15:31:30ZengTaylor & Francis GroupEuropean Journal of Psychotraumatology2000-80662019-12-0110110.1080/20008198.2019.15835251583525Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivityMarie-José van Hoof0Madelon M. E. Riem1Amy S. Garrett2Nic J. A. van der Wee3Marinus H. van IJzendoorn4Robert R. J. M Vermeiren5Leiden University Medical CenterTilburg UniversityUniversity of Texas Health Science CenterLeiden Institute for Brain and Cognition (LIBC)Erasmus UniversityLeiden University Medical CenterBackground: Recent research has identified a general psychopathology factor (GPF), which explains overlap in presentation of psychopathological symptoms. Unresolved–disorganized attachment (Ud) is another transdiagnostic risk factor that may be relevant to explain differences in patient characteristics within diagnostic classifications. Objective: In the current study, we examined unique relations of resting-state functional connectivity (RSFC) with Ud and GPF. Method: RSFC data were collected from a mixed group of adolescents (N = 74) with and without psychiatric disorder, as part of the Emotional Pathways’ Imaging Study in Clinical Adolescents (EPISCA) study. Ud was measured using the Adult Attachment Interview (AAI). Associations between Ud, GPF, and RSFC of the amygdala and dorsal anterior cingulate cortex (dACC) and with amygdala–medial frontal connectivity were examined. Results: Ud was positively associated with greater functional connectivity between the left amygdala and the left lateral occipital cortex, precuneus, and superior parietal lobule. Furthermore, Ud was negatively associated with left amygdala–medial frontal cortex connectivity. GPF was not significantly associated with dACC or amygdala connectivity. Conclusions: Atypical amygdala connectivity may reflect a vulnerability factor rather than a biomarker of psychopathology. The unique association of Ud and amygdala RSFC, adjusted for a GPF, across participants with and without various classifications of psychopathology illustrates that dimensional approaches based on the AAI may complement psychiatric classifications in clinical research and practice.http://dx.doi.org/10.1080/20008198.2019.1583525general psychopathology factorunresolved–disorganized attachmentamygdalaresting-state functional connectivitydorsal anterior cingulate cortexmedial prefrontal cortexpsychopathologyadolescents |
| spellingShingle | Marie-José van Hoof Madelon M. E. Riem Amy S. Garrett Nic J. A. van der Wee Marinus H. van IJzendoorn Robert R. J. M Vermeiren Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity European Journal of Psychotraumatology general psychopathology factor unresolved–disorganized attachment amygdala resting-state functional connectivity dorsal anterior cingulate cortex medial prefrontal cortex psychopathology adolescents |
| title | Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity |
| title_full | Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity |
| title_fullStr | Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity |
| title_full_unstemmed | Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity |
| title_short | Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity |
| title_sort | unresolved disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting state functional connectivity |
| topic | general psychopathology factor unresolved–disorganized attachment amygdala resting-state functional connectivity dorsal anterior cingulate cortex medial prefrontal cortex psychopathology adolescents |
| url | http://dx.doi.org/10.1080/20008198.2019.1583525 |
| work_keys_str_mv | AT mariejosevanhoof unresolveddisorganizedattachmentadjustedforageneralpsychopathologyfactorassociatedwithatypicalamygdalarestingstatefunctionalconnectivity AT madelonmeriem unresolveddisorganizedattachmentadjustedforageneralpsychopathologyfactorassociatedwithatypicalamygdalarestingstatefunctionalconnectivity AT amysgarrett unresolveddisorganizedattachmentadjustedforageneralpsychopathologyfactorassociatedwithatypicalamygdalarestingstatefunctionalconnectivity AT nicjavanderwee unresolveddisorganizedattachmentadjustedforageneralpsychopathologyfactorassociatedwithatypicalamygdalarestingstatefunctionalconnectivity AT marinushvanijzendoorn unresolveddisorganizedattachmentadjustedforageneralpsychopathologyfactorassociatedwithatypicalamygdalarestingstatefunctionalconnectivity AT robertrjmvermeiren unresolveddisorganizedattachmentadjustedforageneralpsychopathologyfactorassociatedwithatypicalamygdalarestingstatefunctionalconnectivity |