Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysis
Abstract Background The frequency, clinical characteristics, and associated symptoms of comorbid tic disorders in individuals with autism spectrum disorder (ASD) remain unclear. Methods We included subsets of individuals from a larger genetic study who were diagnosed with ASD (n = 679; age: 4–18 yea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Child and Adolescent Psychiatry and Mental Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13034-023-00625-8 |
| _version_ | 1797801577412558848 |
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| author | Ye Rim Kim Da-Yea Song Guiyoung Bong Jae Hyun Han Joo-Hyun Kim Hee Jeong Yoo |
| author_facet | Ye Rim Kim Da-Yea Song Guiyoung Bong Jae Hyun Han Joo-Hyun Kim Hee Jeong Yoo |
| author_sort | Ye Rim Kim |
| collection | DOAJ |
| description | Abstract Background The frequency, clinical characteristics, and associated symptoms of comorbid tic disorders in individuals with autism spectrum disorder (ASD) remain unclear. Methods We included subsets of individuals from a larger genetic study who were diagnosed with ASD (n = 679; age: 4–18 years) and completed the Yale Global Tic Severity Scale (YGTSS) questionnaire. Based on the YGTSS score, the individuals were divided into two groups: ASD only (n = 554) and ASD with tics (n = 125). Individuals were assessed using the verbal and non-verbal intelligence quotient (IQ), Vineland Adaptive Behavior Scale (VABS-2), Social Responsiveness Scale-2 (SRS-2), Child Behavior Checklists (CBCL), and Yale-Brown Obsessive–Compulsive Scale (YBOCS), followed by between-group comparisons. All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS) version 26. Results Tic symptoms were observed in 125 (18.4%) participants; among them, most participants presented both motor and vocal tics (n = 40, 40.0%). The ASD with tics group had a significantly higher average age and full-scale IQ score than the ASD only group. After adjusting for age, the ASD with tics group had significantly higher scores in the SRS-2, CBCL, and YBOCS subdomains than the ASD only group. Furthermore, all variables except the non-verbal IQ and VABS-2 scores were positively correlated with the YGTSS total score. Finally, the proportion of tic symptoms was significantly higher among individuals with a higher IQ score (≥ 70). Conclusions The IQ score was positively correlated with the proportion of tic symptoms among individuals with ASD. Moreover, the severity of the core and comorbid symptoms of ASD was associated with the occurrence and severity of tic disorders. Our findings suggest the need for appropriate clinical interventions for individuals with ASD. Trial registration This study retrospectively registered participants |
| first_indexed | 2024-03-13T04:52:52Z |
| format | Article |
| id | doaj.art-7b634a0578f24e969b3242b42e60db97 |
| institution | Directory Open Access Journal |
| issn | 1753-2000 |
| language | English |
| last_indexed | 2024-03-13T04:52:52Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Child and Adolescent Psychiatry and Mental Health |
| spelling | doaj.art-7b634a0578f24e969b3242b42e60db972023-06-18T11:06:43ZengBMCChild and Adolescent Psychiatry and Mental Health1753-20002023-06-011711810.1186/s13034-023-00625-8Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysisYe Rim Kim0Da-Yea Song1Guiyoung Bong2Jae Hyun Han3Joo-Hyun Kim4Hee Jeong Yoo5Department of Psychiatry, Seoul National University Bundang HospitalDepartment of Psychiatry, Seoul National University College of MedicineDepartment of Psychiatry, Seoul National University Bundang HospitalDepartment of Psychiatry, Seoul National University Bundang HospitalDepartment of Psychiatry, Seoul National University Bundang HospitalDepartment of Psychiatry, Seoul National University Bundang HospitalAbstract Background The frequency, clinical characteristics, and associated symptoms of comorbid tic disorders in individuals with autism spectrum disorder (ASD) remain unclear. Methods We included subsets of individuals from a larger genetic study who were diagnosed with ASD (n = 679; age: 4–18 years) and completed the Yale Global Tic Severity Scale (YGTSS) questionnaire. Based on the YGTSS score, the individuals were divided into two groups: ASD only (n = 554) and ASD with tics (n = 125). Individuals were assessed using the verbal and non-verbal intelligence quotient (IQ), Vineland Adaptive Behavior Scale (VABS-2), Social Responsiveness Scale-2 (SRS-2), Child Behavior Checklists (CBCL), and Yale-Brown Obsessive–Compulsive Scale (YBOCS), followed by between-group comparisons. All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS) version 26. Results Tic symptoms were observed in 125 (18.4%) participants; among them, most participants presented both motor and vocal tics (n = 40, 40.0%). The ASD with tics group had a significantly higher average age and full-scale IQ score than the ASD only group. After adjusting for age, the ASD with tics group had significantly higher scores in the SRS-2, CBCL, and YBOCS subdomains than the ASD only group. Furthermore, all variables except the non-verbal IQ and VABS-2 scores were positively correlated with the YGTSS total score. Finally, the proportion of tic symptoms was significantly higher among individuals with a higher IQ score (≥ 70). Conclusions The IQ score was positively correlated with the proportion of tic symptoms among individuals with ASD. Moreover, the severity of the core and comorbid symptoms of ASD was associated with the occurrence and severity of tic disorders. Our findings suggest the need for appropriate clinical interventions for individuals with ASD. Trial registration This study retrospectively registered participantshttps://doi.org/10.1186/s13034-023-00625-8Autism spectrum disorderTic disorderYale Global Tic Severity ScaleIntelligence QuotientComorbidity |
| spellingShingle | Ye Rim Kim Da-Yea Song Guiyoung Bong Jae Hyun Han Joo-Hyun Kim Hee Jeong Yoo Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysis Child and Adolescent Psychiatry and Mental Health Autism spectrum disorder Tic disorder Yale Global Tic Severity Scale Intelligence Quotient Comorbidity |
| title | Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysis |
| title_full | Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysis |
| title_fullStr | Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysis |
| title_full_unstemmed | Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysis |
| title_short | Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysis |
| title_sort | clinical characteristics of comorbid tic disorders in autism spectrum disorder exploratory analysis |
| topic | Autism spectrum disorder Tic disorder Yale Global Tic Severity Scale Intelligence Quotient Comorbidity |
| url | https://doi.org/10.1186/s13034-023-00625-8 |
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