Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis.
We investigated two important means for improving source reconstruction in presurgical epilepsy diagnosis. The first investigation is about the optimal choice of the number of epileptic spikes in averaging to (1) sufficiently reduce the noise bias for an accurate determination of the center of gravi...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0118753 |
| _version_ | 1818724936357773312 |
|---|---|
| author | Ümit Aydin Johannes Vorwerk Matthias Dümpelmann Philipp Küpper Harald Kugel Marcel Heers Jörg Wellmer Christoph Kellinghaus Jens Haueisen Stefan Rampp Hermann Stefan Carsten H Wolters |
| author_facet | Ümit Aydin Johannes Vorwerk Matthias Dümpelmann Philipp Küpper Harald Kugel Marcel Heers Jörg Wellmer Christoph Kellinghaus Jens Haueisen Stefan Rampp Hermann Stefan Carsten H Wolters |
| author_sort | Ümit Aydin |
| collection | DOAJ |
| description | We investigated two important means for improving source reconstruction in presurgical epilepsy diagnosis. The first investigation is about the optimal choice of the number of epileptic spikes in averaging to (1) sufficiently reduce the noise bias for an accurate determination of the center of gravity of the epileptic activity and (2) still get an estimation of the extent of the irritative zone. The second study focuses on the differences in single modality EEG (80-electrodes) or MEG (275-gradiometers) and especially on the benefits of combined EEG/MEG (EMEG) source analysis. Both investigations were validated with simultaneous stereo-EEG (sEEG) (167-contacts) and low-density EEG (ldEEG) (21-electrodes). To account for the different sensitivity profiles of EEG and MEG, we constructed a six-compartment finite element head model with anisotropic white matter conductivity, and calibrated the skull conductivity via somatosensory evoked responses. Our results show that, unlike single modality EEG or MEG, combined EMEG uses the complementary information of both modalities and thereby allows accurate source reconstructions also at early instants in time (epileptic spike onset), i.e., time points with low SNR, which are not yet subject to propagation and thus supposed to be closer to the origin of the epileptic activity. EMEG is furthermore able to reveal the propagation pathway at later time points in agreement with sEEG, while EEG or MEG alone reconstructed only parts of it. Subaveraging provides important and accurate information about both the center of gravity and the extent of the epileptogenic tissue that neither single nor grand-averaged spike localizations can supply. |
| first_indexed | 2024-12-17T21:34:20Z |
| format | Article |
| id | doaj.art-7b660f6ab8db4c0fa6067f335a02af6d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T21:34:20Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7b660f6ab8db4c0fa6067f335a02af6d2022-12-21T21:31:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011875310.1371/journal.pone.0118753Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis.Ümit AydinJohannes VorwerkMatthias DümpelmannPhilipp KüpperHarald KugelMarcel HeersJörg WellmerChristoph KellinghausJens HaueisenStefan RamppHermann StefanCarsten H WoltersWe investigated two important means for improving source reconstruction in presurgical epilepsy diagnosis. The first investigation is about the optimal choice of the number of epileptic spikes in averaging to (1) sufficiently reduce the noise bias for an accurate determination of the center of gravity of the epileptic activity and (2) still get an estimation of the extent of the irritative zone. The second study focuses on the differences in single modality EEG (80-electrodes) or MEG (275-gradiometers) and especially on the benefits of combined EEG/MEG (EMEG) source analysis. Both investigations were validated with simultaneous stereo-EEG (sEEG) (167-contacts) and low-density EEG (ldEEG) (21-electrodes). To account for the different sensitivity profiles of EEG and MEG, we constructed a six-compartment finite element head model with anisotropic white matter conductivity, and calibrated the skull conductivity via somatosensory evoked responses. Our results show that, unlike single modality EEG or MEG, combined EMEG uses the complementary information of both modalities and thereby allows accurate source reconstructions also at early instants in time (epileptic spike onset), i.e., time points with low SNR, which are not yet subject to propagation and thus supposed to be closer to the origin of the epileptic activity. EMEG is furthermore able to reveal the propagation pathway at later time points in agreement with sEEG, while EEG or MEG alone reconstructed only parts of it. Subaveraging provides important and accurate information about both the center of gravity and the extent of the epileptogenic tissue that neither single nor grand-averaged spike localizations can supply.https://doi.org/10.1371/journal.pone.0118753 |
| spellingShingle | Ümit Aydin Johannes Vorwerk Matthias Dümpelmann Philipp Küpper Harald Kugel Marcel Heers Jörg Wellmer Christoph Kellinghaus Jens Haueisen Stefan Rampp Hermann Stefan Carsten H Wolters Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis. PLoS ONE |
| title | Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis. |
| title_full | Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis. |
| title_fullStr | Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis. |
| title_full_unstemmed | Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis. |
| title_short | Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis. |
| title_sort | combined eeg meg can outperform single modality eeg or meg source reconstruction in presurgical epilepsy diagnosis |
| url | https://doi.org/10.1371/journal.pone.0118753 |
| work_keys_str_mv | AT umitaydin combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT johannesvorwerk combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT matthiasdumpelmann combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT philippkupper combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT haraldkugel combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT marcelheers combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT jorgwellmer combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT christophkellinghaus combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT jenshaueisen combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT stefanrampp combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT hermannstefan combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis AT carstenhwolters combinedeegmegcanoutperformsinglemodalityeegormegsourcereconstructioninpresurgicalepilepsydiagnosis |