Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers
This is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the limitations of published evidence of cut-off values and their sensitivities and specificities. Maternal risk fa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.840288/full |
| _version_ | 1819104181194063872 |
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| author | Julia Eichberger Elisabeth Resch Bernhard Resch Bernhard Resch |
| author_facet | Julia Eichberger Elisabeth Resch Bernhard Resch Bernhard Resch |
| author_sort | Julia Eichberger |
| collection | DOAJ |
| description | This is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the limitations of published evidence of cut-off values and their sensitivities and specificities. Maternal risk factors influence the results of inflammatory markers as do gestational age, the time of sampling, the use of either cord blood or neonatal peripheral blood, and some non-infectious causes. Current evidence suggests that the use of promising diagnostic markers such as CD11b, CD64, IL-6, IL-8, PCT, and CRP, either alone or in combination, might enable clinicians discontinuing antibiotics confidently within 24–48 h. However, none of the current diagnostic markers is sensitive and specific enough to support the decision of withholding antibiotic treatment without considering clinical findings. It therefore seems to be justified that antibiotics are often initiated in ill term and especially preterm infants. Early markers like IL-6 and later markers like CRP are helpful in the diagnosis of neonatal sepsis considering the clinical aspect of the neonate, the gestational age, maternal risk factors and the time (age of the neonate regarding early-onset sepsis) of blood sampling. |
| first_indexed | 2024-12-22T02:02:16Z |
| format | Article |
| id | doaj.art-7b67c4ef1d34418e8dab1d068e1ac404 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-22T02:02:16Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-7b67c4ef1d34418e8dab1d068e1ac4042022-12-21T18:42:37ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-03-011010.3389/fped.2022.840288840288Diagnosis of Neonatal Sepsis: The Role of Inflammatory MarkersJulia Eichberger0Elisabeth Resch1Bernhard Resch2Bernhard Resch3Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaThis is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the limitations of published evidence of cut-off values and their sensitivities and specificities. Maternal risk factors influence the results of inflammatory markers as do gestational age, the time of sampling, the use of either cord blood or neonatal peripheral blood, and some non-infectious causes. Current evidence suggests that the use of promising diagnostic markers such as CD11b, CD64, IL-6, IL-8, PCT, and CRP, either alone or in combination, might enable clinicians discontinuing antibiotics confidently within 24–48 h. However, none of the current diagnostic markers is sensitive and specific enough to support the decision of withholding antibiotic treatment without considering clinical findings. It therefore seems to be justified that antibiotics are often initiated in ill term and especially preterm infants. Early markers like IL-6 and later markers like CRP are helpful in the diagnosis of neonatal sepsis considering the clinical aspect of the neonate, the gestational age, maternal risk factors and the time (age of the neonate regarding early-onset sepsis) of blood sampling.https://www.frontiersin.org/articles/10.3389/fped.2022.840288/fullearly onset sepsislate onset sepsispreterm/full term infantsinflammatory markerinterleukin-6C-reactive protein (CRP) |
| spellingShingle | Julia Eichberger Elisabeth Resch Bernhard Resch Bernhard Resch Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers Frontiers in Pediatrics early onset sepsis late onset sepsis preterm/full term infants inflammatory marker interleukin-6 C-reactive protein (CRP) |
| title | Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers |
| title_full | Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers |
| title_fullStr | Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers |
| title_full_unstemmed | Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers |
| title_short | Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers |
| title_sort | diagnosis of neonatal sepsis the role of inflammatory markers |
| topic | early onset sepsis late onset sepsis preterm/full term infants inflammatory marker interleukin-6 C-reactive protein (CRP) |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.840288/full |
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