COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19
Background: Patients with coronavirus infectious disease 2019 (COVID-19) and gastrointestinal symptoms showed increased values of fecal calprotectin (FC). Additionally, bowel abnormalities were a common finding during abdominal imaging of individuals with COVID-19 despite being asymptomatic. The cur...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/5/3/147 |
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| author | Mauro Giuffrè Stefano Di Bella Gianluca Sambataro Verena Zerbato Marco Cavallaro Alessandro Agostino Occhipinti Andrea Palermo Anna Crescenzi Fabio Monica Roberto Luzzati Lory Saveria Crocè |
| author_facet | Mauro Giuffrè Stefano Di Bella Gianluca Sambataro Verena Zerbato Marco Cavallaro Alessandro Agostino Occhipinti Andrea Palermo Anna Crescenzi Fabio Monica Roberto Luzzati Lory Saveria Crocè |
| author_sort | Mauro Giuffrè |
| collection | DOAJ |
| description | Background: Patients with coronavirus infectious disease 2019 (COVID-19) and gastrointestinal symptoms showed increased values of fecal calprotectin (FC). Additionally, bowel abnormalities were a common finding during abdominal imaging of individuals with COVID-19 despite being asymptomatic. The current pilot study aims at evaluating FC concentrations in patients without gastrointestinal symptoms. Methods: we enrolled 25 consecutive inpatients with COVID-19 pneumonia, who were admitted without gastrointestinal symptoms and a previous history of inflammatory bowel disease. Results: At admission, 21 patients showed increased FC with median values of 116 (87.5; 243.5) mg/kg despite absent gastrointestinal symptoms. We found a strong positive correlation between FC and D-Dimer (r = 0.745, <i>p</i> < 0.0001). Two patients developed bowel perforation. Conclusion: our findings may change the current understanding of COVID-19 intestinal-related disease pathogenesis, shedding new light on the potential role of thrombosis and the consequent hypoxic intestinal damage. |
| first_indexed | 2024-03-10T16:18:39Z |
| format | Article |
| id | doaj.art-7b6a4d26cc4646f5901b2c95cab57dbe |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T16:18:39Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-7b6a4d26cc4646f5901b2c95cab57dbe2023-11-20T13:52:38ZengMDPI AGTropical Medicine and Infectious Disease2414-63662020-09-015314710.3390/tropicalmed5030147COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19Mauro Giuffrè0Stefano Di Bella1Gianluca Sambataro2Verena Zerbato3Marco Cavallaro4Alessandro Agostino Occhipinti5Andrea Palermo6Anna Crescenzi7Fabio Monica8Roberto Luzzati9Lory Saveria Crocè10Department of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, ItalyDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, ItalyUniversity Hospital “Policlinico-Vittorio Emanuele”, Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, ItalyInfectious Diseases Department, Udine University, 33100 Udine, ItalyDepartment of Radiology, Trieste University Hospital, 34139 Trieste, ItalyEmergency Department, Trieste University Hospital, 34139 Trieste, ItalyUnit of Endocrinology and Diabetes, Campus Bio-Medico University, 00128 Rome, ItalySection of Pathology, Campus Bio-Medico University, 00128 Rome, ItalyDepartment of Gastroenterology, Trieste University Hospital, 34139 Trieste, ItalyDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, ItalyDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, ItalyBackground: Patients with coronavirus infectious disease 2019 (COVID-19) and gastrointestinal symptoms showed increased values of fecal calprotectin (FC). Additionally, bowel abnormalities were a common finding during abdominal imaging of individuals with COVID-19 despite being asymptomatic. The current pilot study aims at evaluating FC concentrations in patients without gastrointestinal symptoms. Methods: we enrolled 25 consecutive inpatients with COVID-19 pneumonia, who were admitted without gastrointestinal symptoms and a previous history of inflammatory bowel disease. Results: At admission, 21 patients showed increased FC with median values of 116 (87.5; 243.5) mg/kg despite absent gastrointestinal symptoms. We found a strong positive correlation between FC and D-Dimer (r = 0.745, <i>p</i> < 0.0001). Two patients developed bowel perforation. Conclusion: our findings may change the current understanding of COVID-19 intestinal-related disease pathogenesis, shedding new light on the potential role of thrombosis and the consequent hypoxic intestinal damage.https://www.mdpi.com/2414-6366/5/3/147fecal calprotectinCOVID-19SARS-CoV-2bowel perforationD-Dimerthrombosis |
| spellingShingle | Mauro Giuffrè Stefano Di Bella Gianluca Sambataro Verena Zerbato Marco Cavallaro Alessandro Agostino Occhipinti Andrea Palermo Anna Crescenzi Fabio Monica Roberto Luzzati Lory Saveria Crocè COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19 Tropical Medicine and Infectious Disease fecal calprotectin COVID-19 SARS-CoV-2 bowel perforation D-Dimer thrombosis |
| title | COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19 |
| title_full | COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19 |
| title_fullStr | COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19 |
| title_full_unstemmed | COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19 |
| title_short | COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19 |
| title_sort | covid 19 induced thrombosis in patients without gastrointestinal symptoms and elevated fecal calprotectin hypothesis regarding mechanism of intestinal damage associated with covid 19 |
| topic | fecal calprotectin COVID-19 SARS-CoV-2 bowel perforation D-Dimer thrombosis |
| url | https://www.mdpi.com/2414-6366/5/3/147 |
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