A Fast Ubiquitination of UHRF1 Oncogene Is a Unique Feature and a Common Mechanism of Thymoquinone in Cancer Cells

A Fast Ubiquitination of UHRF1 Oncogene Is a Unique Feature and a Common Mechanism of Thymoquinone in Cancer Cells

Downregulation of the ubiquitin-like containing PHD and ring finger 1 (UHRF1) oncogene in cancer cells in response to natural anticancer drugs, including thymoquinone (TQ), is a key event that induces apoptosis. TQ can induce UHRF1 autoubiquitination via the E3 ligase activity of its RING domain, mo...

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Bibliographic Details
Main Authors: Mahmoud Alhosin, Omeima Abdullah, Asaad Kayali, Ziad Omran
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Applied Sciences
Subjects:
thymoquinone
UHRF1
ubiquitination
HAUSP
tumor suppressor genes
Online Access:https://www.mdpi.com/2076-3417/11/16/7633

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