Bacteriophage therapy for drug-resistant Staphylococcus aureus infections
Drug-resistant Staphylococcus aureus stands as a prominent pathogen in nosocomial and community-acquired infections, capable of inciting various infections at different sites in patients. This includes Staphylococcus aureus bacteremia (SaB), which exhibits a severe infection frequently associated wi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1336821/full |
| _version_ | 1797338426135019520 |
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| author | Kaixin Liu Kaixin Liu Chao Wang Xudong Zhou Xudong Zhou Xudong Guo Yi Yang Wanying Liu Rongtao Zhao Hongbin Song Hongbin Song Hongbin Song |
| author_facet | Kaixin Liu Kaixin Liu Chao Wang Xudong Zhou Xudong Zhou Xudong Guo Yi Yang Wanying Liu Rongtao Zhao Hongbin Song Hongbin Song Hongbin Song |
| author_sort | Kaixin Liu |
| collection | DOAJ |
| description | Drug-resistant Staphylococcus aureus stands as a prominent pathogen in nosocomial and community-acquired infections, capable of inciting various infections at different sites in patients. This includes Staphylococcus aureus bacteremia (SaB), which exhibits a severe infection frequently associated with significant mortality rate of approximately 25%. In the absence of better alternative therapies, antibiotics is still the main approach for treating infections. However, excessive use of antibiotics has, in turn, led to an increase in antimicrobial resistance. Hence, it is imperative that new strategies are developed to control drug-resistant S. aureus infections. Bacteriophages are viruses with the ability to infect bacteria. Bacteriophages, were used to treat bacterial infections before the advent of antibiotics, but were subsequently replaced by antibiotics due to limited theoretical understanding and inefficient preparation processes at the time. Recently, phages have attracted the attention of many researchers again because of the serious problem of antibiotic resistance. This article provides a comprehensive overview of phage biology, animal models, diverse clinical case treatments, and clinical trials in the context of drug-resistant S. aureus phage therapy. It also assesses the strengths and limitations of phage therapy and outlines the future prospects and research directions. This review is expected to offer valuable insights for researchers engaged in phage-based treatments for drug-resistant S. aureus infections. |
| first_indexed | 2024-03-08T09:30:02Z |
| format | Article |
| id | doaj.art-7b6cca3e8dcc42ba89f72e61e5456500 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-08T09:30:02Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-7b6cca3e8dcc42ba89f72e61e54565002024-01-31T04:37:54ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-01-011410.3389/fcimb.2024.13368211336821Bacteriophage therapy for drug-resistant Staphylococcus aureus infectionsKaixin Liu0Kaixin Liu1Chao Wang2Xudong Zhou3Xudong Zhou4Xudong Guo5Yi Yang6Wanying Liu7Rongtao Zhao8Hongbin Song9Hongbin Song10Hongbin Song11College of Public Health, Zhengzhou University, Zhengzhou, ChinaChinese PLA Center for Disease Control and Prevention, Beijing, ChinaChinese PLA Center for Disease Control and Prevention, Beijing, ChinaChinese PLA Center for Disease Control and Prevention, Beijing, ChinaCollege of Public Health, China Medical University, Shenyang, ChinaChinese PLA Center for Disease Control and Prevention, Beijing, ChinaChinese PLA Center for Disease Control and Prevention, Beijing, ChinaChinese PLA Center for Disease Control and Prevention, Beijing, ChinaChinese PLA Center for Disease Control and Prevention, Beijing, ChinaCollege of Public Health, Zhengzhou University, Zhengzhou, ChinaChinese PLA Center for Disease Control and Prevention, Beijing, ChinaCollege of Public Health, China Medical University, Shenyang, ChinaDrug-resistant Staphylococcus aureus stands as a prominent pathogen in nosocomial and community-acquired infections, capable of inciting various infections at different sites in patients. This includes Staphylococcus aureus bacteremia (SaB), which exhibits a severe infection frequently associated with significant mortality rate of approximately 25%. In the absence of better alternative therapies, antibiotics is still the main approach for treating infections. However, excessive use of antibiotics has, in turn, led to an increase in antimicrobial resistance. Hence, it is imperative that new strategies are developed to control drug-resistant S. aureus infections. Bacteriophages are viruses with the ability to infect bacteria. Bacteriophages, were used to treat bacterial infections before the advent of antibiotics, but were subsequently replaced by antibiotics due to limited theoretical understanding and inefficient preparation processes at the time. Recently, phages have attracted the attention of many researchers again because of the serious problem of antibiotic resistance. This article provides a comprehensive overview of phage biology, animal models, diverse clinical case treatments, and clinical trials in the context of drug-resistant S. aureus phage therapy. It also assesses the strengths and limitations of phage therapy and outlines the future prospects and research directions. This review is expected to offer valuable insights for researchers engaged in phage-based treatments for drug-resistant S. aureus infections.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1336821/fullbacteriophagesdrug-resistant Staphylococcus aureusinfectionbacteriophage therapyantimicrobial resistance |
| spellingShingle | Kaixin Liu Kaixin Liu Chao Wang Xudong Zhou Xudong Zhou Xudong Guo Yi Yang Wanying Liu Rongtao Zhao Hongbin Song Hongbin Song Hongbin Song Bacteriophage therapy for drug-resistant Staphylococcus aureus infections Frontiers in Cellular and Infection Microbiology bacteriophages drug-resistant Staphylococcus aureus infection bacteriophage therapy antimicrobial resistance |
| title | Bacteriophage therapy for drug-resistant Staphylococcus aureus infections |
| title_full | Bacteriophage therapy for drug-resistant Staphylococcus aureus infections |
| title_fullStr | Bacteriophage therapy for drug-resistant Staphylococcus aureus infections |
| title_full_unstemmed | Bacteriophage therapy for drug-resistant Staphylococcus aureus infections |
| title_short | Bacteriophage therapy for drug-resistant Staphylococcus aureus infections |
| title_sort | bacteriophage therapy for drug resistant staphylococcus aureus infections |
| topic | bacteriophages drug-resistant Staphylococcus aureus infection bacteriophage therapy antimicrobial resistance |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1336821/full |
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