Coagulopathy in pediatric acute promyelocytic leukemia in Bangladesh: A single-center, prospective study
Background: Acute promyelocytic leukemia (APL) is one of the most curable subtypes of acute myeloid leukemia in childhood. It usually presents with a characteristic coagulopathy. The aim of the study was to determine the extent and outcome of this coagulation disorder. Methods: This prospective obse...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Pediatric Hematology Oncology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468124524000317 |
| _version_ | 1797205981109682176 |
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| author | Eshita Reza Khan Ferdousi Begum Afiqul Islam K.M. Ahasan Ahmed |
| author_facet | Eshita Reza Khan Ferdousi Begum Afiqul Islam K.M. Ahasan Ahmed |
| author_sort | Eshita Reza Khan |
| collection | DOAJ |
| description | Background: Acute promyelocytic leukemia (APL) is one of the most curable subtypes of acute myeloid leukemia in childhood. It usually presents with a characteristic coagulopathy. The aim of the study was to determine the extent and outcome of this coagulation disorder. Methods: This prospective observational study was conducted at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, and included PML:RAR-α (Promyelocytic Leukemia-Retinoic Acid Receptor-α) positive APL cases. At presentation, all patients were assessed with coagulation parameters and followed up clinically and hematologically while treated with ATRA (all-trans-retinoic acid)-based chemotherapy. The presence of disseminated intravascular coagulation (DIC) was determined using the DIC scoring system of the International Society on Thrombosis and Hemostasis (ISTH). Results: Among 20 APL cases, the mean DIC score was 5.75 ± 0.6. DIC was detected in 90% (n = 18/20) of the patients. The incidence of fatal thrombo-hemorrhagic complications was 15% (n = 3/20). Though hemorrhagic complications are common, thrombosis may also occur in pediatric APL. |
| first_indexed | 2024-04-24T08:59:45Z |
| format | Article |
| id | doaj.art-7b6f1fb45251474b99784d0457787ecd |
| institution | Directory Open Access Journal |
| issn | 2468-1245 |
| language | English |
| last_indexed | 2024-04-24T08:59:45Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatric Hematology Oncology Journal |
| spelling | doaj.art-7b6f1fb45251474b99784d0457787ecd2024-04-16T04:09:48ZengElsevierPediatric Hematology Oncology Journal2468-12452024-06-0192114119Coagulopathy in pediatric acute promyelocytic leukemia in Bangladesh: A single-center, prospective studyEshita Reza Khan0Ferdousi Begum1Afiqul Islam2K.M. Ahasan Ahmed3Department of Pediatric Hematology and Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh; Corresponding author.Department of Pediatric Hematology and Oncology, National Institute of Cancer Research and Hospital, Dhaka, BangladeshDepartment of Pediatric Hematology and Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshNational Institute of Neurosciences Hospital, Dhaka, BangladeshBackground: Acute promyelocytic leukemia (APL) is one of the most curable subtypes of acute myeloid leukemia in childhood. It usually presents with a characteristic coagulopathy. The aim of the study was to determine the extent and outcome of this coagulation disorder. Methods: This prospective observational study was conducted at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, and included PML:RAR-α (Promyelocytic Leukemia-Retinoic Acid Receptor-α) positive APL cases. At presentation, all patients were assessed with coagulation parameters and followed up clinically and hematologically while treated with ATRA (all-trans-retinoic acid)-based chemotherapy. The presence of disseminated intravascular coagulation (DIC) was determined using the DIC scoring system of the International Society on Thrombosis and Hemostasis (ISTH). Results: Among 20 APL cases, the mean DIC score was 5.75 ± 0.6. DIC was detected in 90% (n = 18/20) of the patients. The incidence of fatal thrombo-hemorrhagic complications was 15% (n = 3/20). Though hemorrhagic complications are common, thrombosis may also occur in pediatric APL.http://www.sciencedirect.com/science/article/pii/S2468124524000317APLPediatricCoagulopathyBangladeshLMICHemorrhage |
| spellingShingle | Eshita Reza Khan Ferdousi Begum Afiqul Islam K.M. Ahasan Ahmed Coagulopathy in pediatric acute promyelocytic leukemia in Bangladesh: A single-center, prospective study Pediatric Hematology Oncology Journal APL Pediatric Coagulopathy Bangladesh LMIC Hemorrhage |
| title | Coagulopathy in pediatric acute promyelocytic leukemia in Bangladesh: A single-center, prospective study |
| title_full | Coagulopathy in pediatric acute promyelocytic leukemia in Bangladesh: A single-center, prospective study |
| title_fullStr | Coagulopathy in pediatric acute promyelocytic leukemia in Bangladesh: A single-center, prospective study |
| title_full_unstemmed | Coagulopathy in pediatric acute promyelocytic leukemia in Bangladesh: A single-center, prospective study |
| title_short | Coagulopathy in pediatric acute promyelocytic leukemia in Bangladesh: A single-center, prospective study |
| title_sort | coagulopathy in pediatric acute promyelocytic leukemia in bangladesh a single center prospective study |
| topic | APL Pediatric Coagulopathy Bangladesh LMIC Hemorrhage |
| url | http://www.sciencedirect.com/science/article/pii/S2468124524000317 |
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