Autoimmune antibodies in first-episode psychosis with red flags: A hospital-based case-control study protocol
BackgroundResearch is increasingly identifying an overlap between psychosis and immunological dysregulation. Certain autoantibodies are being identified in a small but probably relevant subgroup of patients with psychosis. The term “autoimmune psychosis” (AIP) and its corresponding red-flag signs pr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.976159/full |
| _version_ | 1828727809173880832 |
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| author | Jianjun Wang Jianjun Wang Jianjun Wang Xuan Liu Xuan Liu Jie Lian Jie Lian Haotao Zheng Haotao Zheng Dongbin Cai Dongbin Cai Haobin Cai Haobin Cai Dan Zhou Dan Zhou Songjun Lin Songjun Lin Fanxin Kong Fanxin Kong Xiude Qin Xiude Qin Jianqiang Bi |
| author_facet | Jianjun Wang Jianjun Wang Jianjun Wang Xuan Liu Xuan Liu Jie Lian Jie Lian Haotao Zheng Haotao Zheng Dongbin Cai Dongbin Cai Haobin Cai Haobin Cai Dan Zhou Dan Zhou Songjun Lin Songjun Lin Fanxin Kong Fanxin Kong Xiude Qin Xiude Qin Jianqiang Bi |
| author_sort | Jianjun Wang |
| collection | DOAJ |
| description | BackgroundResearch is increasingly identifying an overlap between psychosis and immunological dysregulation. Certain autoantibodies are being identified in a small but probably relevant subgroup of patients with psychosis. The term “autoimmune psychosis” (AIP) and its corresponding red-flag signs present the opportunity for a new field in psychiatry to promote diagnostic workup and immunomodulating therapy in individual cases.ObjectivesThe present protocol aims to determine the seroprevalence of autoantibodies in first-episode psychosis (FEPs) using AIP red flag signs, and to explore the frequency of autoantibody subtypes and potential mediating confounders.Methods/designThis is a hospital-based case-control study. All participants will be consecutively selected from the main tertiary psychiatric hospital in Shenzhen City, China. Individuals admitted to the psychiatric ward and diagnosed with FEPs will be enrolled. Based on recent consensus, participants with red flags of AIPs will be defined as cases, while the remainder will be matched as controls. Seropositive antibodies will be detected and verified in cerebrospinal fluid (CSF) samples based on the fixed cell-based assay (CBA) method. The propensity score-adjusted odds ratios will be determined to investigate the key mediating confounders regarding autoantibody subtypes and red flag subsets.DiscussionThe results of this study will facilitate the early identification of AIPs in FEP patients using the red flag sign and help identify key mediators that improve the accuracy of diagnostic algorithms. It will have clinical significance to focus on serum antibodies that have been verified in CSF samples, due to its consistency with clinical practices in current psychiatry. |
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| format | Article |
| id | doaj.art-7b6f2e8d4b9e46d0a77b9bfbd350b36a |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T14:05:31Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-7b6f2e8d4b9e46d0a77b9bfbd350b36a2022-12-22T03:30:06ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-10-011310.3389/fpsyt.2022.976159976159Autoimmune antibodies in first-episode psychosis with red flags: A hospital-based case-control study protocolJianjun Wang0Jianjun Wang1Jianjun Wang2Xuan Liu3Xuan Liu4Jie Lian5Jie Lian6Haotao Zheng7Haotao Zheng8Dongbin Cai9Dongbin Cai10Haobin Cai11Haobin Cai12Dan Zhou13Dan Zhou14Songjun Lin15Songjun Lin16Fanxin Kong17Fanxin Kong18Xiude Qin19Xiude Qin20Jianqiang Bi21Department of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaGlobal Clinical Scholars Research Training, Harvard Medical School, Boston, MA, United StatesDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Laboratory Medicine, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Public Health, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, ChinaBackgroundResearch is increasingly identifying an overlap between psychosis and immunological dysregulation. Certain autoantibodies are being identified in a small but probably relevant subgroup of patients with psychosis. The term “autoimmune psychosis” (AIP) and its corresponding red-flag signs present the opportunity for a new field in psychiatry to promote diagnostic workup and immunomodulating therapy in individual cases.ObjectivesThe present protocol aims to determine the seroprevalence of autoantibodies in first-episode psychosis (FEPs) using AIP red flag signs, and to explore the frequency of autoantibody subtypes and potential mediating confounders.Methods/designThis is a hospital-based case-control study. All participants will be consecutively selected from the main tertiary psychiatric hospital in Shenzhen City, China. Individuals admitted to the psychiatric ward and diagnosed with FEPs will be enrolled. Based on recent consensus, participants with red flags of AIPs will be defined as cases, while the remainder will be matched as controls. Seropositive antibodies will be detected and verified in cerebrospinal fluid (CSF) samples based on the fixed cell-based assay (CBA) method. The propensity score-adjusted odds ratios will be determined to investigate the key mediating confounders regarding autoantibody subtypes and red flag subsets.DiscussionThe results of this study will facilitate the early identification of AIPs in FEP patients using the red flag sign and help identify key mediators that improve the accuracy of diagnostic algorithms. It will have clinical significance to focus on serum antibodies that have been verified in CSF samples, due to its consistency with clinical practices in current psychiatry.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.976159/fullfirst-episode psychosis (FEP)autoimmuneautoantibodyred flagN-methyl-D-aspartate receptors (NMDAR) |
| spellingShingle | Jianjun Wang Jianjun Wang Jianjun Wang Xuan Liu Xuan Liu Jie Lian Jie Lian Haotao Zheng Haotao Zheng Dongbin Cai Dongbin Cai Haobin Cai Haobin Cai Dan Zhou Dan Zhou Songjun Lin Songjun Lin Fanxin Kong Fanxin Kong Xiude Qin Xiude Qin Jianqiang Bi Autoimmune antibodies in first-episode psychosis with red flags: A hospital-based case-control study protocol Frontiers in Psychiatry first-episode psychosis (FEP) autoimmune autoantibody red flag N-methyl-D-aspartate receptors (NMDAR) |
| title | Autoimmune antibodies in first-episode psychosis with red flags: A hospital-based case-control study protocol |
| title_full | Autoimmune antibodies in first-episode psychosis with red flags: A hospital-based case-control study protocol |
| title_fullStr | Autoimmune antibodies in first-episode psychosis with red flags: A hospital-based case-control study protocol |
| title_full_unstemmed | Autoimmune antibodies in first-episode psychosis with red flags: A hospital-based case-control study protocol |
| title_short | Autoimmune antibodies in first-episode psychosis with red flags: A hospital-based case-control study protocol |
| title_sort | autoimmune antibodies in first episode psychosis with red flags a hospital based case control study protocol |
| topic | first-episode psychosis (FEP) autoimmune autoantibody red flag N-methyl-D-aspartate receptors (NMDAR) |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.976159/full |
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