PUFAs add fuel to Crohn’s disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation

PUFAs add fuel to Crohn’s disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation

ABSTRACTPolyunsaturated fatty acids (PUFAs) have been shown to exacerbate Crohn’s disease (CD) by promoting lipid peroxidation (LPO) of intestinal epithelial cells (IECs). Dysbiosis of the gut microbiota may play a crucial role in this process. CD patients often exhibit an increased abundance of Esc...

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Bibliographic Details
Main Authors: Weiwei Wen, Yihan Xu, Wenwei Qian, Liangyu Huang, Jianfeng Gong, Yi Li, Weiming Zhu, Zhen Guo
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Crohn’s disease
polyunsaturated fatty acids
GPX4
ferroptosis
lipid peroxidation
adherent-invasive Escherichia coli
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2265578

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