MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats
Pathologic cardiac remodeling and dysfunction are the most common complications of type 2 diabetes. Physical exercise is important in inhibiting myocardial pathologic remodeling and restoring cardiac function in diabetes. The mitochondrial-derived peptide MOTS-c has exercise-like effects by improvin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.812032/full |
| _version_ | 1818335169634893824 |
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| author | Shunchang Li Manda Wang Jiacheng Ma Xiaoli Pang Jinghan Yuan Yanrong Pan Yu Fu Ismail Laher |
| author_facet | Shunchang Li Manda Wang Jiacheng Ma Xiaoli Pang Jinghan Yuan Yanrong Pan Yu Fu Ismail Laher |
| author_sort | Shunchang Li |
| collection | DOAJ |
| description | Pathologic cardiac remodeling and dysfunction are the most common complications of type 2 diabetes. Physical exercise is important in inhibiting myocardial pathologic remodeling and restoring cardiac function in diabetes. The mitochondrial-derived peptide MOTS-c has exercise-like effects by improving insulin resistance, combatting hyperglycemia, and reducing lipid accumulation. We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin. Both aerobic exercise and MOTS-c treatment reduced abnormalities in cardiac structure and function. Transcriptomic function enrichment analysis revealed that MOTS-c had exercise-like effects on inflammation, myocardial apoptosis, angiogenesis and endothelial cell proliferation and migration, and showed that the NRG1-ErbB4 pathway might be an important component in both MOTS-c and exercise induced attenuation of cardiac dysfunction in diabetes. Moreover, our findings suggest that MOTS-c activates NRG1-ErbB4 signaling and mimics exercise-induced cardio-protection in diabetes. |
| first_indexed | 2024-12-13T14:19:09Z |
| format | Article |
| id | doaj.art-7b7129dfa9df41a48b4e123a8d6097c6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T14:19:09Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7b7129dfa9df41a48b4e123a8d6097c62022-12-21T23:42:09ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-03-011310.3389/fendo.2022.812032812032MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic RatsShunchang Li0Manda Wang1Jiacheng Ma2Xiaoli Pang3Jinghan Yuan4Yanrong Pan5Yu Fu6Ismail Laher7Institute of Sports Medicine and Health, Chengdu Sport University, Chengdu, ChinaInstitute of Sports Medicine and Health, Chengdu Sport University, Chengdu, ChinaInstitute of Sports Medicine and Health, Chengdu Sport University, Chengdu, ChinaInstitute of Sports Medicine and Health, Chengdu Sport University, Chengdu, ChinaInstitute of Sports Medicine and Health, Chengdu Sport University, Chengdu, ChinaInstitute of Sports Medicine and Health, Chengdu Sport University, Chengdu, ChinaInstitute of Sports Medicine and Health, Chengdu Sport University, Chengdu, ChinaDepartment of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, CanadaPathologic cardiac remodeling and dysfunction are the most common complications of type 2 diabetes. Physical exercise is important in inhibiting myocardial pathologic remodeling and restoring cardiac function in diabetes. The mitochondrial-derived peptide MOTS-c has exercise-like effects by improving insulin resistance, combatting hyperglycemia, and reducing lipid accumulation. We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin. Both aerobic exercise and MOTS-c treatment reduced abnormalities in cardiac structure and function. Transcriptomic function enrichment analysis revealed that MOTS-c had exercise-like effects on inflammation, myocardial apoptosis, angiogenesis and endothelial cell proliferation and migration, and showed that the NRG1-ErbB4 pathway might be an important component in both MOTS-c and exercise induced attenuation of cardiac dysfunction in diabetes. Moreover, our findings suggest that MOTS-c activates NRG1-ErbB4 signaling and mimics exercise-induced cardio-protection in diabetes.https://www.frontiersin.org/articles/10.3389/fendo.2022.812032/fullMOTS-caerobic exercisetype 2 diabetes (T2D)myocardiumtranscriptome |
| spellingShingle | Shunchang Li Manda Wang Jiacheng Ma Xiaoli Pang Jinghan Yuan Yanrong Pan Yu Fu Ismail Laher MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats Frontiers in Endocrinology MOTS-c aerobic exercise type 2 diabetes (T2D) myocardium transcriptome |
| title | MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats |
| title_full | MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats |
| title_fullStr | MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats |
| title_full_unstemmed | MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats |
| title_short | MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats |
| title_sort | mots c and exercise restore cardiac function by activating of nrg1 erbb signaling in diabetic rats |
| topic | MOTS-c aerobic exercise type 2 diabetes (T2D) myocardium transcriptome |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.812032/full |
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