MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats

MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats

Pathologic cardiac remodeling and dysfunction are the most common complications of type 2 diabetes. Physical exercise is important in inhibiting myocardial pathologic remodeling and restoring cardiac function in diabetes. The mitochondrial-derived peptide MOTS-c has exercise-like effects by improvin...

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Bibliographic Details
Main Authors: Shunchang Li, Manda Wang, Jiacheng Ma, Xiaoli Pang, Jinghan Yuan, Yanrong Pan, Yu Fu, Ismail Laher
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Endocrinology
Subjects:
MOTS-c
aerobic exercise
type 2 diabetes (T2D)
myocardium
transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.812032/full

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