PET/CT for Predicting Occult Lymph Node Metastasis in Gastric Cancer
A portion of gastric cancer patients with negative lymph node metastasis at an early stage eventually die from tumor recurrence or advanced metastasis. Occult lymph node metastasis (OLNM] is a potential risk factor for the recurrence and metastasis in these patients, and it is highly important for c...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/29/9/513 |
| _version_ | 1827662000055910400 |
|---|---|
| author | Danyu Ma Ying Zhang Xiaoliang Shao Chen Wu Jun Wu |
| author_facet | Danyu Ma Ying Zhang Xiaoliang Shao Chen Wu Jun Wu |
| author_sort | Danyu Ma |
| collection | DOAJ |
| description | A portion of gastric cancer patients with negative lymph node metastasis at an early stage eventually die from tumor recurrence or advanced metastasis. Occult lymph node metastasis (OLNM] is a potential risk factor for the recurrence and metastasis in these patients, and it is highly important for clinical prognosis. Positron emission tomography (PET)/computed tomography (CT) is used to assess lymph node metastasis in gastric cancer due to its advantages in anatomical and functional imaging and non-invasive nature. Among the major metabolic parameters of PET, the maximum standardized uptake value (SUVmax) is commonly used for examining lymph node status. However, SUVmax is susceptible to interference by a variety of factors. In recent years, the exploration of new PET metabolic parameters, new PET imaging agents and radiomics, has become an active research topic. This paper aims to explore the feasibility and predict the effectiveness of using PET/CT to detect OLNM. The current landscape and future trends of primary metabolic parameters and new imaging agents of PET are reviewed. For gastric cancer patients, the possibility to detect OLNM non-invasively will help guide surgeons to choose the appropriate lymph node dissection area, thereby reducing unnecessary dissections and providing more reasonable, personalized and comprehensive treatments. |
| first_indexed | 2024-03-10T00:19:01Z |
| format | Article |
| id | doaj.art-7b76fd02632d49f68d8996f76e99a21c |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T00:19:01Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-7b76fd02632d49f68d8996f76e99a21c2023-11-23T15:46:05ZengMDPI AGCurrent Oncology1198-00521718-77292022-09-012996523653910.3390/curroncol29090513PET/CT for Predicting Occult Lymph Node Metastasis in Gastric CancerDanyu Ma0Ying Zhang1Xiaoliang Shao2Chen Wu3Jun Wu4Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, ChinaDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou 213003, ChinaDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, ChinaDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, ChinaA portion of gastric cancer patients with negative lymph node metastasis at an early stage eventually die from tumor recurrence or advanced metastasis. Occult lymph node metastasis (OLNM] is a potential risk factor for the recurrence and metastasis in these patients, and it is highly important for clinical prognosis. Positron emission tomography (PET)/computed tomography (CT) is used to assess lymph node metastasis in gastric cancer due to its advantages in anatomical and functional imaging and non-invasive nature. Among the major metabolic parameters of PET, the maximum standardized uptake value (SUVmax) is commonly used for examining lymph node status. However, SUVmax is susceptible to interference by a variety of factors. In recent years, the exploration of new PET metabolic parameters, new PET imaging agents and radiomics, has become an active research topic. This paper aims to explore the feasibility and predict the effectiveness of using PET/CT to detect OLNM. The current landscape and future trends of primary metabolic parameters and new imaging agents of PET are reviewed. For gastric cancer patients, the possibility to detect OLNM non-invasively will help guide surgeons to choose the appropriate lymph node dissection area, thereby reducing unnecessary dissections and providing more reasonable, personalized and comprehensive treatments.https://www.mdpi.com/1718-7729/29/9/513gastric cancerlymph nodesoccult lymph node metastasisPET/CTmaximum standardized uptake value (SUVmax)radiomics |
| spellingShingle | Danyu Ma Ying Zhang Xiaoliang Shao Chen Wu Jun Wu PET/CT for Predicting Occult Lymph Node Metastasis in Gastric Cancer Current Oncology gastric cancer lymph nodes occult lymph node metastasis PET/CT maximum standardized uptake value (SUVmax) radiomics |
| title | PET/CT for Predicting Occult Lymph Node Metastasis in Gastric Cancer |
| title_full | PET/CT for Predicting Occult Lymph Node Metastasis in Gastric Cancer |
| title_fullStr | PET/CT for Predicting Occult Lymph Node Metastasis in Gastric Cancer |
| title_full_unstemmed | PET/CT for Predicting Occult Lymph Node Metastasis in Gastric Cancer |
| title_short | PET/CT for Predicting Occult Lymph Node Metastasis in Gastric Cancer |
| title_sort | pet ct for predicting occult lymph node metastasis in gastric cancer |
| topic | gastric cancer lymph nodes occult lymph node metastasis PET/CT maximum standardized uptake value (SUVmax) radiomics |
| url | https://www.mdpi.com/1718-7729/29/9/513 |
| work_keys_str_mv | AT danyuma petctforpredictingoccultlymphnodemetastasisingastriccancer AT yingzhang petctforpredictingoccultlymphnodemetastasisingastriccancer AT xiaoliangshao petctforpredictingoccultlymphnodemetastasisingastriccancer AT chenwu petctforpredictingoccultlymphnodemetastasisingastriccancer AT junwu petctforpredictingoccultlymphnodemetastasisingastriccancer |