Extended Ligation of the Hepatic Vein May Yield a Similar Effect to Liver Venous Deprivation in a Rat Model
Aims To validate the hypothesis that hepatic vein ligation (HVL) alone may produce similar results to liver venous deprivation (LVD or HVL + portal vein ligation [PVL]). Methods Rats were assigned to five groups, namely, the control group; the R group in which the right median hepatic vein (RMHV) wa...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2023.2214620 |
| _version_ | 1797684411073822720 |
|---|---|
| author | Xiaoqin He Yuefeng Zhang Gaoshuo Zhang Peng Ma Liangkun Xiong Wei Wang Yangtao Xu Yang Shen Kaihuan Yu Weixing Wang |
| author_facet | Xiaoqin He Yuefeng Zhang Gaoshuo Zhang Peng Ma Liangkun Xiong Wei Wang Yangtao Xu Yang Shen Kaihuan Yu Weixing Wang |
| author_sort | Xiaoqin He |
| collection | DOAJ |
| description | Aims To validate the hypothesis that hepatic vein ligation (HVL) alone may produce similar results to liver venous deprivation (LVD or HVL + portal vein ligation [PVL]). Methods Rats were assigned to five groups, namely, the control group; the R group in which the right median hepatic vein (RMHV) was ligated; the M group in which the middle median hepatic vein (MMHV) was ligated; the RM group in which both the RMHV and MMHV were ligated (R + MMHVL, extended ligation of the hepatic veins); and the LVD group in which both the right median portal vein and the RMHV were ligated. The liver hypertrophy effect and liver enzymes were determined. Methylene blue staining and retrograde pressurized perfusion assays were performed to investigate the hemodynamic changes. Results The RM and LVD groups exhibited similar significant hypertrophy in the future liver remnants when compared to that of the control group, and almost no additional hypertrophy effect was observed in the R and M groups. There was a remarkable elevation in serum transaminase levels in both groups. The methylene blue staining experiment indicated that pressure-dependent collaterals formed between the contiguous drainage areas, and the R + MMHVL procedure blocked the outflow of the right median lobe. Conclusion Extended ligation of the hepatic vein (R + MMHVL) resulted in a similar hypertrophy effect and hepatic damage to those of LVD (HVL + PVL) treatment in a rat model, and intrahepatic venovenous collaterals play key roles. |
| first_indexed | 2024-03-12T00:30:15Z |
| format | Article |
| id | doaj.art-7b790b7f40294946a759f981ed77daf0 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:30:15Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-7b790b7f40294946a759f981ed77daf02023-09-15T10:21:31ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532023-12-0136110.1080/08941939.2023.22146202214620Extended Ligation of the Hepatic Vein May Yield a Similar Effect to Liver Venous Deprivation in a Rat ModelXiaoqin He0Yuefeng Zhang1Gaoshuo Zhang2Peng Ma3Liangkun Xiong4Wei Wang5Yangtao Xu6Yang Shen7Kaihuan Yu8Weixing Wang9Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan UniversityDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan UniversityDepartment of Teaching Office, Renmin Hospital of Wuhan UniversityDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan UniversityDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan UniversityDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan UniversityThe First Clinical College, Wuhan UniversityThe First Clinical College, Wuhan UniversityDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan UniversityDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan UniversityAims To validate the hypothesis that hepatic vein ligation (HVL) alone may produce similar results to liver venous deprivation (LVD or HVL + portal vein ligation [PVL]). Methods Rats were assigned to five groups, namely, the control group; the R group in which the right median hepatic vein (RMHV) was ligated; the M group in which the middle median hepatic vein (MMHV) was ligated; the RM group in which both the RMHV and MMHV were ligated (R + MMHVL, extended ligation of the hepatic veins); and the LVD group in which both the right median portal vein and the RMHV were ligated. The liver hypertrophy effect and liver enzymes were determined. Methylene blue staining and retrograde pressurized perfusion assays were performed to investigate the hemodynamic changes. Results The RM and LVD groups exhibited similar significant hypertrophy in the future liver remnants when compared to that of the control group, and almost no additional hypertrophy effect was observed in the R and M groups. There was a remarkable elevation in serum transaminase levels in both groups. The methylene blue staining experiment indicated that pressure-dependent collaterals formed between the contiguous drainage areas, and the R + MMHVL procedure blocked the outflow of the right median lobe. Conclusion Extended ligation of the hepatic vein (R + MMHVL) resulted in a similar hypertrophy effect and hepatic damage to those of LVD (HVL + PVL) treatment in a rat model, and intrahepatic venovenous collaterals play key roles.http://dx.doi.org/10.1080/08941939.2023.2214620liver venous deprivationhepatic vein ligationhypertrophyanimal model |
| spellingShingle | Xiaoqin He Yuefeng Zhang Gaoshuo Zhang Peng Ma Liangkun Xiong Wei Wang Yangtao Xu Yang Shen Kaihuan Yu Weixing Wang Extended Ligation of the Hepatic Vein May Yield a Similar Effect to Liver Venous Deprivation in a Rat Model Journal of Investigative Surgery liver venous deprivation hepatic vein ligation hypertrophy animal model |
| title | Extended Ligation of the Hepatic Vein May Yield a Similar Effect to Liver Venous Deprivation in a Rat Model |
| title_full | Extended Ligation of the Hepatic Vein May Yield a Similar Effect to Liver Venous Deprivation in a Rat Model |
| title_fullStr | Extended Ligation of the Hepatic Vein May Yield a Similar Effect to Liver Venous Deprivation in a Rat Model |
| title_full_unstemmed | Extended Ligation of the Hepatic Vein May Yield a Similar Effect to Liver Venous Deprivation in a Rat Model |
| title_short | Extended Ligation of the Hepatic Vein May Yield a Similar Effect to Liver Venous Deprivation in a Rat Model |
| title_sort | extended ligation of the hepatic vein may yield a similar effect to liver venous deprivation in a rat model |
| topic | liver venous deprivation hepatic vein ligation hypertrophy animal model |
| url | http://dx.doi.org/10.1080/08941939.2023.2214620 |
| work_keys_str_mv | AT xiaoqinhe extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel AT yuefengzhang extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel AT gaoshuozhang extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel AT pengma extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel AT liangkunxiong extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel AT weiwang extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel AT yangtaoxu extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel AT yangshen extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel AT kaihuanyu extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel AT weixingwang extendedligationofthehepaticveinmayyieldasimilareffecttolivervenousdeprivationinaratmodel |