Flexible Fiber Probe for Efficient Neural Stimulation and Detection
Abstract Functional probes are a leading contender for the recognition and manipulation of nervous behavior and are characterized by substantial scientific and technological potential. Despite the recent development of functional neural probes, a flexible biocompatible probe unit that allows for lon...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-08-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202001410 |
| _version_ | 1818843126278651904 |
|---|---|
| author | Minghui Du Lu Huang Jiajun Zheng Yue Xi Yi Dai Weida Zhang Wei Yan Guangming Tao Jianrong Qiu Kwok‐Fai So Chaoran Ren Shifeng Zhou |
| author_facet | Minghui Du Lu Huang Jiajun Zheng Yue Xi Yi Dai Weida Zhang Wei Yan Guangming Tao Jianrong Qiu Kwok‐Fai So Chaoran Ren Shifeng Zhou |
| author_sort | Minghui Du |
| collection | DOAJ |
| description | Abstract Functional probes are a leading contender for the recognition and manipulation of nervous behavior and are characterized by substantial scientific and technological potential. Despite the recent development of functional neural probes, a flexible biocompatible probe unit that allows for long‐term simultaneous stimulation and signaling is still an important task. Here, a category of flexible tiny multimaterial fiber probes (<0.3 g) is described in which the metal electrodes are regularly embedded inside a biocompatible polymer fiber with a double‐clad optical waveguide by thermal drawing. Significantly, this arrangement enables great improvement in mechanical properties, achieves high optical transmission (>90%), and effectively minimizes the impedance (by up to one order of magnitude) of the probe. This ability allows to realize long‐term (at least 10 weeks) simultaneous optical stimulation and neural recording at the single‐cell level in behaving mice with signal‐to‐noise ratio (SNR = 30 dB) that is more than 6 times that of the benchmark probe such as an all‐polymer fiber. |
| first_indexed | 2024-12-19T04:52:55Z |
| format | Article |
| id | doaj.art-7b79d43f5e17452db0a28c9134b88822 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-19T04:52:55Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-7b79d43f5e17452db0a28c9134b888222022-12-21T20:35:18ZengWileyAdvanced Science2198-38442020-08-01715n/an/a10.1002/advs.202001410Flexible Fiber Probe for Efficient Neural Stimulation and DetectionMinghui Du0Lu Huang1Jiajun Zheng2Yue Xi3Yi Dai4Weida Zhang5Wei Yan6Guangming Tao7Jianrong Qiu8Kwok‐Fai So9Chaoran Ren10Shifeng Zhou11State Key Laboratory of Luminescent Materials and Devices School of Materials Science and Engineering South China University of Technology Guangzhou 510640 ChinaGuangdong‐Hongkong‐Macau Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Guangzhou 510632 ChinaGuangdong‐Hongkong‐Macau Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Guangzhou 510632 ChinaGuangdong‐Hongkong‐Macau Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Guangzhou 510632 ChinaState Key Laboratory of Luminescent Materials and Devices School of Materials Science and Engineering South China University of Technology Guangzhou 510640 ChinaState Key Laboratory of Luminescent Materials and Devices School of Materials Science and Engineering South China University of Technology Guangzhou 510640 ChinaResearch Laboratory of Electronics Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USASchool of Optical and Electronic Information Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 ChinaCollege of Optical Science and Engineering State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 ChinaGuangdong‐Hongkong‐Macau Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Guangzhou 510632 ChinaGuangdong‐Hongkong‐Macau Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Guangzhou 510632 ChinaState Key Laboratory of Luminescent Materials and Devices School of Materials Science and Engineering South China University of Technology Guangzhou 510640 ChinaAbstract Functional probes are a leading contender for the recognition and manipulation of nervous behavior and are characterized by substantial scientific and technological potential. Despite the recent development of functional neural probes, a flexible biocompatible probe unit that allows for long‐term simultaneous stimulation and signaling is still an important task. Here, a category of flexible tiny multimaterial fiber probes (<0.3 g) is described in which the metal electrodes are regularly embedded inside a biocompatible polymer fiber with a double‐clad optical waveguide by thermal drawing. Significantly, this arrangement enables great improvement in mechanical properties, achieves high optical transmission (>90%), and effectively minimizes the impedance (by up to one order of magnitude) of the probe. This ability allows to realize long‐term (at least 10 weeks) simultaneous optical stimulation and neural recording at the single‐cell level in behaving mice with signal‐to‐noise ratio (SNR = 30 dB) that is more than 6 times that of the benchmark probe such as an all‐polymer fiber.https://doi.org/10.1002/advs.202001410brain–machine interfacesflexible fiber probesneural recordingneural stimulationoptogenetics |
| spellingShingle | Minghui Du Lu Huang Jiajun Zheng Yue Xi Yi Dai Weida Zhang Wei Yan Guangming Tao Jianrong Qiu Kwok‐Fai So Chaoran Ren Shifeng Zhou Flexible Fiber Probe for Efficient Neural Stimulation and Detection Advanced Science brain–machine interfaces flexible fiber probes neural recording neural stimulation optogenetics |
| title | Flexible Fiber Probe for Efficient Neural Stimulation and Detection |
| title_full | Flexible Fiber Probe for Efficient Neural Stimulation and Detection |
| title_fullStr | Flexible Fiber Probe for Efficient Neural Stimulation and Detection |
| title_full_unstemmed | Flexible Fiber Probe for Efficient Neural Stimulation and Detection |
| title_short | Flexible Fiber Probe for Efficient Neural Stimulation and Detection |
| title_sort | flexible fiber probe for efficient neural stimulation and detection |
| topic | brain–machine interfaces flexible fiber probes neural recording neural stimulation optogenetics |
| url | https://doi.org/10.1002/advs.202001410 |
| work_keys_str_mv | AT minghuidu flexiblefiberprobeforefficientneuralstimulationanddetection AT luhuang flexiblefiberprobeforefficientneuralstimulationanddetection AT jiajunzheng flexiblefiberprobeforefficientneuralstimulationanddetection AT yuexi flexiblefiberprobeforefficientneuralstimulationanddetection AT yidai flexiblefiberprobeforefficientneuralstimulationanddetection AT weidazhang flexiblefiberprobeforefficientneuralstimulationanddetection AT weiyan flexiblefiberprobeforefficientneuralstimulationanddetection AT guangmingtao flexiblefiberprobeforefficientneuralstimulationanddetection AT jianrongqiu flexiblefiberprobeforefficientneuralstimulationanddetection AT kwokfaiso flexiblefiberprobeforefficientneuralstimulationanddetection AT chaoranren flexiblefiberprobeforefficientneuralstimulationanddetection AT shifengzhou flexiblefiberprobeforefficientneuralstimulationanddetection |