RNAME: A comprehensive database of RNA modification enzymes
The dynamic RNA modifications were orchestrated by a series of enzymes, namely “writer”, “reader” and “eraser”, which can install, recognize and remove the modifications, respectively. However, only a very small number of experimentally validated RNA modification enzymes have been identified and rep...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
|
| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037022005165 |
| _version_ | 1797978156676677632 |
|---|---|
| author | Fulei Nie Qiang Tang Ying Liu Huaizhi Qin Shilong Liu Meng Wu Pengmian Feng Wei Chen |
| author_facet | Fulei Nie Qiang Tang Ying Liu Huaizhi Qin Shilong Liu Meng Wu Pengmian Feng Wei Chen |
| author_sort | Fulei Nie |
| collection | DOAJ |
| description | The dynamic RNA modifications were orchestrated by a series of enzymes, namely “writer”, “reader” and “eraser”, which can install, recognize and remove the modifications, respectively. However, only a very small number of experimentally validated RNA modification enzymes have been identified and reported. Therefore, there is an urgent need to develop a database to deposit RNA modification enzymes. In the present work, we developed the RNAME database (https://chenweilab.cn/rname/) to provide a comprehensive resource for RNA modification enzymes. The current version of RNAME deposits more than 21,000 manually curated RNA modification enzymes, which are from 456 species and covers the 7 common kinds of RNA modifications (i.e., adenosine to inosine, N1-methyladenosine, N6-methyladenosine, 5-methylcytidine, N7-methylguanosine, mRNA cap modification, and pseudouridine). The 3D structures, domains, subcellular locations, and biological functions of these enzymes were also integrated in RNAME. It is anticipated that RNAME will facilitate the researches on RNA modifications. |
| first_indexed | 2024-04-11T05:18:28Z |
| format | Article |
| id | doaj.art-7b7be7500075486292e2df9791b6c964 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-04-11T05:18:28Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-7b7be7500075486292e2df9791b6c9642022-12-24T04:55:12ZengElsevierComputational and Structural Biotechnology Journal2001-03702022-01-012062446249RNAME: A comprehensive database of RNA modification enzymesFulei Nie0Qiang Tang1Ying Liu2Huaizhi Qin3Shilong Liu4Meng Wu5Pengmian Feng6Wei Chen7School of Public Health, North China University of Science and Technology, Tangshan 063210, China; School of Life Sciences, North China University of Science and Technology, Tangshan 063210, ChinaSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSchool of Life Sciences, North China University of Science and Technology, Tangshan 063210, ChinaSchool of Life Sciences, North China University of Science and Technology, Tangshan 063210, ChinaSchool of Life Sciences, North China University of Science and Technology, Tangshan 063210, ChinaSchool of Life Sciences, North China University of Science and Technology, Tangshan 063210, ChinaSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Corresponding authors at: School of Public Health, North China University of Science and Technology, Tangshan 063210, China.School of Public Health, North China University of Science and Technology, Tangshan 063210, China; School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China; School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Corresponding authors at: School of Public Health, North China University of Science and Technology, Tangshan 063210, China.The dynamic RNA modifications were orchestrated by a series of enzymes, namely “writer”, “reader” and “eraser”, which can install, recognize and remove the modifications, respectively. However, only a very small number of experimentally validated RNA modification enzymes have been identified and reported. Therefore, there is an urgent need to develop a database to deposit RNA modification enzymes. In the present work, we developed the RNAME database (https://chenweilab.cn/rname/) to provide a comprehensive resource for RNA modification enzymes. The current version of RNAME deposits more than 21,000 manually curated RNA modification enzymes, which are from 456 species and covers the 7 common kinds of RNA modifications (i.e., adenosine to inosine, N1-methyladenosine, N6-methyladenosine, 5-methylcytidine, N7-methylguanosine, mRNA cap modification, and pseudouridine). The 3D structures, domains, subcellular locations, and biological functions of these enzymes were also integrated in RNAME. It is anticipated that RNAME will facilitate the researches on RNA modifications.http://www.sciencedirect.com/science/article/pii/S2001037022005165RNA modificationsRNA modification enzymesWriterReaderEraserDatabase |
| spellingShingle | Fulei Nie Qiang Tang Ying Liu Huaizhi Qin Shilong Liu Meng Wu Pengmian Feng Wei Chen RNAME: A comprehensive database of RNA modification enzymes Computational and Structural Biotechnology Journal RNA modifications RNA modification enzymes Writer Reader Eraser Database |
| title | RNAME: A comprehensive database of RNA modification enzymes |
| title_full | RNAME: A comprehensive database of RNA modification enzymes |
| title_fullStr | RNAME: A comprehensive database of RNA modification enzymes |
| title_full_unstemmed | RNAME: A comprehensive database of RNA modification enzymes |
| title_short | RNAME: A comprehensive database of RNA modification enzymes |
| title_sort | rname a comprehensive database of rna modification enzymes |
| topic | RNA modifications RNA modification enzymes Writer Reader Eraser Database |
| url | http://www.sciencedirect.com/science/article/pii/S2001037022005165 |
| work_keys_str_mv | AT fuleinie rnameacomprehensivedatabaseofrnamodificationenzymes AT qiangtang rnameacomprehensivedatabaseofrnamodificationenzymes AT yingliu rnameacomprehensivedatabaseofrnamodificationenzymes AT huaizhiqin rnameacomprehensivedatabaseofrnamodificationenzymes AT shilongliu rnameacomprehensivedatabaseofrnamodificationenzymes AT mengwu rnameacomprehensivedatabaseofrnamodificationenzymes AT pengmianfeng rnameacomprehensivedatabaseofrnamodificationenzymes AT weichen rnameacomprehensivedatabaseofrnamodificationenzymes |