Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR.
BACKGROUND:Patients after transcatheter aortic valve replacement (TAVR) and persistent severe mitral regurgitation (MR) are increasingly treated with percutaneous edge-to-edge mitral valve repair (PMVR). The impact of a former TAVR on PMVR procedures is not clear. METHODS AND RESULTS:We retrospectiv...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6195292?pdf=render |
| _version_ | 1818252430803992576 |
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| author | Johannes Patzelt Miriam Ulrich Annika Becker Karin A L Müller Rezo Jorbenadze Michal Droppa Wenzhong Zhang Sarah Mandel Lisa Habel Henning Lausberg Janine Pöss Tobias Geisler Oliver Borst Peter Rosenberger Christian Schlensak Meinrad Gawaz Jürgen Schreieck Peter Seizer Harald F Langer |
| author_facet | Johannes Patzelt Miriam Ulrich Annika Becker Karin A L Müller Rezo Jorbenadze Michal Droppa Wenzhong Zhang Sarah Mandel Lisa Habel Henning Lausberg Janine Pöss Tobias Geisler Oliver Borst Peter Rosenberger Christian Schlensak Meinrad Gawaz Jürgen Schreieck Peter Seizer Harald F Langer |
| author_sort | Johannes Patzelt |
| collection | DOAJ |
| description | BACKGROUND:Patients after transcatheter aortic valve replacement (TAVR) and persistent severe mitral regurgitation (MR) are increasingly treated with percutaneous edge-to-edge mitral valve repair (PMVR). The impact of a former TAVR on PMVR procedures is not clear. METHODS AND RESULTS:We retrospectively analyzed 332 patients undergoing PMVR using the MitraClip system with respect to procedural and clinical outcome. 21 of these 332 patients underwent TAVR before PMVR. Intra-procedural transthoracic (TTE) and transesophageal echocardiograms (TEE) immediately before and after clip implantation as well as invasive hemodynamic measurements were evaluated. At baseline, we found a significantly smaller mitral valve anterior-posterior diameter in the TAVR cohort (p < 0.001). A reduction of MR by at least three grades was achieved in a smaller fraction in the TAVR cohort as compared to the cohort with a native aortic valve (p = 0.02). Accordingly, we observed a smaller post-procedural cardiac output in the TAVR cohort (p = 0.02). CONCLUSION:PMVR in patients who had a TAVR before, is associated with altered MR anatomy before and a reduced improvement of MR after the procedure. Future larger and prospective studies will have to determine, whether a previous TAVR influences long-term clinical outcome of patients undergoing PMVR. |
| first_indexed | 2024-12-12T16:24:03Z |
| format | Article |
| id | doaj.art-7b7c063099c64a57a0348d2d15097df4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T16:24:03Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7b7c063099c64a57a0348d2d15097df42022-12-22T00:18:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020593010.1371/journal.pone.0205930Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR.Johannes PatzeltMiriam UlrichAnnika BeckerKarin A L MüllerRezo JorbenadzeMichal DroppaWenzhong ZhangSarah MandelLisa HabelHenning LausbergJanine PössTobias GeislerOliver BorstPeter RosenbergerChristian SchlensakMeinrad GawazJürgen SchreieckPeter SeizerHarald F LangerBACKGROUND:Patients after transcatheter aortic valve replacement (TAVR) and persistent severe mitral regurgitation (MR) are increasingly treated with percutaneous edge-to-edge mitral valve repair (PMVR). The impact of a former TAVR on PMVR procedures is not clear. METHODS AND RESULTS:We retrospectively analyzed 332 patients undergoing PMVR using the MitraClip system with respect to procedural and clinical outcome. 21 of these 332 patients underwent TAVR before PMVR. Intra-procedural transthoracic (TTE) and transesophageal echocardiograms (TEE) immediately before and after clip implantation as well as invasive hemodynamic measurements were evaluated. At baseline, we found a significantly smaller mitral valve anterior-posterior diameter in the TAVR cohort (p < 0.001). A reduction of MR by at least three grades was achieved in a smaller fraction in the TAVR cohort as compared to the cohort with a native aortic valve (p = 0.02). Accordingly, we observed a smaller post-procedural cardiac output in the TAVR cohort (p = 0.02). CONCLUSION:PMVR in patients who had a TAVR before, is associated with altered MR anatomy before and a reduced improvement of MR after the procedure. Future larger and prospective studies will have to determine, whether a previous TAVR influences long-term clinical outcome of patients undergoing PMVR.http://europepmc.org/articles/PMC6195292?pdf=render |
| spellingShingle | Johannes Patzelt Miriam Ulrich Annika Becker Karin A L Müller Rezo Jorbenadze Michal Droppa Wenzhong Zhang Sarah Mandel Lisa Habel Henning Lausberg Janine Pöss Tobias Geisler Oliver Borst Peter Rosenberger Christian Schlensak Meinrad Gawaz Jürgen Schreieck Peter Seizer Harald F Langer Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR. PLoS ONE |
| title | Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR. |
| title_full | Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR. |
| title_fullStr | Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR. |
| title_full_unstemmed | Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR. |
| title_short | Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR. |
| title_sort | previous tavr in patients undergoing percutaneous edge to edge mitral valve repair pmvr affects improvement of mr |
| url | http://europepmc.org/articles/PMC6195292?pdf=render |
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