Neurological Symptoms of COVID-19: The Zonulin Hypothesis

Neurological Symptoms of COVID-19: The Zonulin Hypothesis

The irruption of SARS-CoV-2 during 2020 has been of pandemic proportions due to its rapid spread and virulence. COVID-19 patients experience respiratory, digestive and neurological symptoms. Distinctive symptom as anosmia, suggests a potential neurotropism of this virus. Amongst the several pathways...

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Bibliographic Details
Main Authors: Sílvia Llorens, Eduardo Nava, Mónica Muñoz-López, Álvaro Sánchez-Larsen, Tomás Segura
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
zonulin
Toll-like receptor4
tight junctions
blood-brain barrier
neurological symptoms
gastrointestinal symptoms
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.665300/full
Description
Summary:The irruption of SARS-CoV-2 during 2020 has been of pandemic proportions due to its rapid spread and virulence. COVID-19 patients experience respiratory, digestive and neurological symptoms. Distinctive symptom as anosmia, suggests a potential neurotropism of this virus. Amongst the several pathways of entry to the nervous system, we propose an alternative pathway from the infection of the gut, involving Toll-like receptor 4 (TLR4), zonulin, protease-activated receptor 2 (PAR2) and zonulin brain receptor. Possible use of zonulin antagonists could be investigated to attenuate neurological manifestations caused by SARS-CoV-19 infection.
ISSN:1664-3224

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