Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats
Background: Consumption of chronic morphine induces neuro-inflammation and addictive seeking behavior. Ginger (Zingiber Officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments. It has been shown that ginger has anti-inflammatory, anti-...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2014-06-01
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| Series: | Addiction and Health |
| Subjects: | |
| Online Access: | https://ahj.kmu.ac.ir/article_84617_e016a94a0dcb915e580f32defd07094e.pdf |
| _version_ | 1797681866824744960 |
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| author | Shima Torkzadeh-Mahani Sima Nasri Saeed Esmaeili-Mahani |
| author_facet | Shima Torkzadeh-Mahani Sima Nasri Saeed Esmaeili-Mahani |
| author_sort | Shima Torkzadeh-Mahani |
| collection | DOAJ |
| description | Background: Consumption of chronic morphine induces neuro-inflammation and addictive seeking behavior. Ginger (Zingiber Officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments. It has been shown that ginger has anti-inflammatory, anti-oxidative and antinociceptive properties. However, its influences on morphine-induced addictive behaviors have not yet been clarified. Methods: For conditioning to the morphine, the male Wistar rats received morphine (12 mg/kg intraperitoneally or i.p.) for 6 consecutive days and treatment groups were given different doses of ginger (25, 50 and 100 mg/kg intragastrically or i.g.) 30 min before morphine injection. For investigating addictive seeking behavior, conditioned place preference test (CPP) was used. Findings: Our result demonstrated that injection of morphine for 6 days induces dependency to morphine and creates addictive seeking behavior and ginger (100 mg/kg) could decrease time spend in conditioning box (addictive seeking behavior). Conclusion: The data indicated that ginger extract has a potential anti-addictive property against chronic usage of morphine. |
| first_indexed | 2024-03-11T23:51:13Z |
| format | Article |
| id | doaj.art-7b7dda25b9fa4055847517156433a75b |
| institution | Directory Open Access Journal |
| issn | 2008-4633 2008-8469 |
| language | English |
| last_indexed | 2024-03-11T23:51:13Z |
| publishDate | 2014-06-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Addiction and Health |
| spelling | doaj.art-7b7dda25b9fa4055847517156433a75b2023-09-19T06:52:45ZengKerman University of Medical SciencesAddiction and Health2008-46332008-84692014-06-0161-2657284617Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in RatsShima Torkzadeh-Mahani0Sima Nasri1Saeed Esmaeili-Mahani2Associate Professor, Department of Biology, Payame Noor University, Tehran Branch, Tehran AND Laboratory of Molecular, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, IranAssociate Professor, Department of Biology, Payame Noor University, Tehran Branch, Tehran, IranAssociate Professor, Department of Biology, School of Sciences, Shahid Bahonar University of Kerman, Kerman, IranBackground: Consumption of chronic morphine induces neuro-inflammation and addictive seeking behavior. Ginger (Zingiber Officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments. It has been shown that ginger has anti-inflammatory, anti-oxidative and antinociceptive properties. However, its influences on morphine-induced addictive behaviors have not yet been clarified. Methods: For conditioning to the morphine, the male Wistar rats received morphine (12 mg/kg intraperitoneally or i.p.) for 6 consecutive days and treatment groups were given different doses of ginger (25, 50 and 100 mg/kg intragastrically or i.g.) 30 min before morphine injection. For investigating addictive seeking behavior, conditioned place preference test (CPP) was used. Findings: Our result demonstrated that injection of morphine for 6 days induces dependency to morphine and creates addictive seeking behavior and ginger (100 mg/kg) could decrease time spend in conditioning box (addictive seeking behavior). Conclusion: The data indicated that ginger extract has a potential anti-addictive property against chronic usage of morphine.https://ahj.kmu.ac.ir/article_84617_e016a94a0dcb915e580f32defd07094e.pdfginger extractmorphineconditioned place preferenceaddictive seeking behaviorrats |
| spellingShingle | Shima Torkzadeh-Mahani Sima Nasri Saeed Esmaeili-Mahani Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats Addiction and Health ginger extract morphine conditioned place preference addictive seeking behavior rats |
| title | Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats |
| title_full | Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats |
| title_fullStr | Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats |
| title_full_unstemmed | Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats |
| title_short | Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats |
| title_sort | ginger zingiber officinale roscoe prevents morphine induced addictive behaviors in conditioned place preference test in rats |
| topic | ginger extract morphine conditioned place preference addictive seeking behavior rats |
| url | https://ahj.kmu.ac.ir/article_84617_e016a94a0dcb915e580f32defd07094e.pdf |
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