Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs Workers
Mycotoxins exposure by inhalation and/or dermal contact is possible in different branches of industry especially where heavily dusty settings are present and the handling of dusty commodities is performed. This study aims to explore the validity of the biomonitoring as a tool to investigate the inta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/11/6/351 |
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| author | Barbara De Santis Francesca Debegnach Elisa Sonego Gianmarco Mazzilli Francesca Buiarelli Fulvio Ferri Paolo Giorgi Rossi Giorgia Collini Carlo Brera |
| author_facet | Barbara De Santis Francesca Debegnach Elisa Sonego Gianmarco Mazzilli Francesca Buiarelli Fulvio Ferri Paolo Giorgi Rossi Giorgia Collini Carlo Brera |
| author_sort | Barbara De Santis |
| collection | DOAJ |
| description | Mycotoxins exposure by inhalation and/or dermal contact is possible in different branches of industry especially where heavily dusty settings are present and the handling of dusty commodities is performed. This study aims to explore the validity of the biomonitoring as a tool to investigate the intake of mycotoxins in a population of workers operating in an Italian feed plant. Serum samples were collected for the determination of aflatoxins B1 (AFB1), AFB1-Lysine adduct and ochratoxin A (OTA). A method based on liquid−liquid extraction coupled with high resolution mass spectrometry determination was developed and fully validated. For AFB1, a high number of non-detected samples (90%) was found and no statistical difference was observed comparing workers and control group. None of the analyzed samples showed the presence of AFB1-Lysine adduct. For OTA, the 100% of the analyzed samples was positive with a 33% of the samples showing a concentration higher than the limit of quantification (LOQ), but no statistical difference was highlighted between the average levels of exposed and control groups. In conclusion, the presence of AFB1 and OTA in serum cannot be attributable to occupational exposure. |
| first_indexed | 2024-04-14T02:24:35Z |
| format | Article |
| id | doaj.art-7b7f89d414104fada5e33f749f5f547b |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-14T02:24:35Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-7b7f89d414104fada5e33f749f5f547b2022-12-22T02:17:56ZengMDPI AGToxins2072-66512019-06-0111635110.3390/toxins11060351toxins11060351Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs WorkersBarbara De Santis0Francesca Debegnach1Elisa Sonego2Gianmarco Mazzilli3Francesca Buiarelli4Fulvio Ferri5Paolo Giorgi Rossi6Giorgia Collini7Carlo Brera8Reparto di Sicurezza Chimica degli Alimenti – Istituto Superiore di Sanità, 00161 Rome, ItalyReparto di Sicurezza Chimica degli Alimenti – Istituto Superiore di Sanità, 00161 Rome, ItalyDipartimento di Chimica – Università “Sapienza”, 00185 Rome, ItalyReparto di Sicurezza Chimica degli Alimenti – Istituto Superiore di Sanità, 00161 Rome, ItalyDipartimento di Chimica – Università “Sapienza”, 00185 Rome, ItalyServizio Prevenzione Sicurezza Ambienti di Lavoro, SPSAL – AUSL, 42122 Reggio Emilia, ItalyServizio Epidemiologia, AUSL – IRCSS di Reggio Emilia, 42122 Reggio Emilia, ItalyServizio Epidemiologia, AUSL – IRCSS di Reggio Emilia, 42122 Reggio Emilia, ItalyReparto di Sicurezza Chimica degli Alimenti – Istituto Superiore di Sanità, 00161 Rome, ItalyMycotoxins exposure by inhalation and/or dermal contact is possible in different branches of industry especially where heavily dusty settings are present and the handling of dusty commodities is performed. This study aims to explore the validity of the biomonitoring as a tool to investigate the intake of mycotoxins in a population of workers operating in an Italian feed plant. Serum samples were collected for the determination of aflatoxins B1 (AFB1), AFB1-Lysine adduct and ochratoxin A (OTA). A method based on liquid−liquid extraction coupled with high resolution mass spectrometry determination was developed and fully validated. For AFB1, a high number of non-detected samples (90%) was found and no statistical difference was observed comparing workers and control group. None of the analyzed samples showed the presence of AFB1-Lysine adduct. For OTA, the 100% of the analyzed samples was positive with a 33% of the samples showing a concentration higher than the limit of quantification (LOQ), but no statistical difference was highlighted between the average levels of exposed and control groups. In conclusion, the presence of AFB1 and OTA in serum cannot be attributable to occupational exposure.https://www.mdpi.com/2072-6651/11/6/351mycotoxinsbiomonitoringaflatoxin B1ochratoxin Aoccupational exposure |
| spellingShingle | Barbara De Santis Francesca Debegnach Elisa Sonego Gianmarco Mazzilli Francesca Buiarelli Fulvio Ferri Paolo Giorgi Rossi Giorgia Collini Carlo Brera Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs Workers Toxins mycotoxins biomonitoring aflatoxin B1 ochratoxin A occupational exposure |
| title | Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs Workers |
| title_full | Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs Workers |
| title_fullStr | Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs Workers |
| title_full_unstemmed | Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs Workers |
| title_short | Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs Workers |
| title_sort | biomonitoring data for assessing aflatoxins and ochratoxin a exposure by italian feedstuffs workers |
| topic | mycotoxins biomonitoring aflatoxin B1 ochratoxin A occupational exposure |
| url | https://www.mdpi.com/2072-6651/11/6/351 |
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