The radioresistant and survival mechanisms of Deinococcus radiodurans
Deinococcus radiodurans (D. radiodurans) is distinguished by the most radioresistant organism ever known, and can tolerate extreme environments such as ionizing radiation, ultraviolet radiation, oxidation, and desiccation. D. radiodurans is an important model for studying DNA damage/repair and redox...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Radiation Medicine and Protection |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666555723000175 |
| _version_ | 1797798608603447296 |
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| author | Feng Liu Nuomin Li Yongqian Zhang |
| author_facet | Feng Liu Nuomin Li Yongqian Zhang |
| author_sort | Feng Liu |
| collection | DOAJ |
| description | Deinococcus radiodurans (D. radiodurans) is distinguished by the most radioresistant organism ever known, and can tolerate extreme environments such as ionizing radiation, ultraviolet radiation, oxidation, and desiccation. D. radiodurans is an important model for studying DNA damage/repair and redox regulation upon high dose ionizing radiation. How D. radiodurans response and repair ROS-induced oxidative damage remains a subject of ongoing investigation. This review provides an overview of the radioresistance characteristics of D. radiodurans. Among them, the DNA damage repair pathway and high-efficiency antioxidant defense system are summarized in detail. Furthermore, a novel model that protects the cell against the ionizing radiation is proposed. This review also discusses the potential application , future challenges and directions in advancing towards D. radiodurans studies. |
| first_indexed | 2024-03-13T04:06:23Z |
| format | Article |
| id | doaj.art-7b800eef9fc7404393d0a34f0fc95ffe |
| institution | Directory Open Access Journal |
| issn | 2666-5557 |
| language | English |
| last_indexed | 2024-03-13T04:06:23Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiation Medicine and Protection |
| spelling | doaj.art-7b800eef9fc7404393d0a34f0fc95ffe2023-06-21T07:00:38ZengElsevierRadiation Medicine and Protection2666-55572023-06-01427079The radioresistant and survival mechanisms of Deinococcus radioduransFeng Liu0Nuomin Li1Yongqian Zhang2School of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaInstitute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, ChinaSchool of Life Science, Beijing Institute of Technology, Beijing 100081, China; Corresponding author.Deinococcus radiodurans (D. radiodurans) is distinguished by the most radioresistant organism ever known, and can tolerate extreme environments such as ionizing radiation, ultraviolet radiation, oxidation, and desiccation. D. radiodurans is an important model for studying DNA damage/repair and redox regulation upon high dose ionizing radiation. How D. radiodurans response and repair ROS-induced oxidative damage remains a subject of ongoing investigation. This review provides an overview of the radioresistance characteristics of D. radiodurans. Among them, the DNA damage repair pathway and high-efficiency antioxidant defense system are summarized in detail. Furthermore, a novel model that protects the cell against the ionizing radiation is proposed. This review also discusses the potential application , future challenges and directions in advancing towards D. radiodurans studies.http://www.sciencedirect.com/science/article/pii/S2666555723000175Deinococcus radioduransRadioresistant mechanismOxidative stressDNA repairAntioxidant defense system |
| spellingShingle | Feng Liu Nuomin Li Yongqian Zhang The radioresistant and survival mechanisms of Deinococcus radiodurans Radiation Medicine and Protection Deinococcus radiodurans Radioresistant mechanism Oxidative stress DNA repair Antioxidant defense system |
| title | The radioresistant and survival mechanisms of Deinococcus radiodurans |
| title_full | The radioresistant and survival mechanisms of Deinococcus radiodurans |
| title_fullStr | The radioresistant and survival mechanisms of Deinococcus radiodurans |
| title_full_unstemmed | The radioresistant and survival mechanisms of Deinococcus radiodurans |
| title_short | The radioresistant and survival mechanisms of Deinococcus radiodurans |
| title_sort | radioresistant and survival mechanisms of deinococcus radiodurans |
| topic | Deinococcus radiodurans Radioresistant mechanism Oxidative stress DNA repair Antioxidant defense system |
| url | http://www.sciencedirect.com/science/article/pii/S2666555723000175 |
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