Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials
Advanced bioceramics for bone regeneration constitutes one of the pivotal interests in the multidisciplinary and far-sighted scientific trajectory of Prof. Vallet Regí. The different pathologies that affect osseous tissue substitution are considered to be one of the most important challenges from th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/11/1981 |
| _version_ | 1797508802229043200 |
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| author | Ana García María Victoria Cabañas Juan Peña Sandra Sánchez-Salcedo |
| author_facet | Ana García María Victoria Cabañas Juan Peña Sandra Sánchez-Salcedo |
| author_sort | Ana García |
| collection | DOAJ |
| description | Advanced bioceramics for bone regeneration constitutes one of the pivotal interests in the multidisciplinary and far-sighted scientific trajectory of Prof. Vallet Regí. The different pathologies that affect osseous tissue substitution are considered to be one of the most important challenges from the health, social and economic point of view. 3D scaffolds based on bioceramics that mimic the composition, environment, microstructure and pore architecture of hard tissues is a consolidated response to such concerns. This review describes not only the different types of materials utilized: from apatite-type to silicon mesoporous materials, but also the fabrication techniques employed to design and adequate microstructure, a hierarchical porosity (from nano to macro scale), a cell-friendly surface; the inclusion of different type of biomolecules, drugs or cells within these scaffolds and the influence on their successful performance is thoughtfully reviewed. |
| first_indexed | 2024-03-10T05:09:03Z |
| format | Article |
| id | doaj.art-7b81a5aebc3f494a91cdd2574fb72341 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T05:09:03Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7b81a5aebc3f494a91cdd2574fb723412023-11-23T01:00:44ZengMDPI AGPharmaceutics1999-49232021-11-011311198110.3390/pharmaceutics13111981Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous MaterialsAna García0María Victoria Cabañas1Juan Peña2Sandra Sánchez-Salcedo3Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, Instituto de Investigación Hospital 12 de Octubre, i+12, 28040 Madrid, SpainDepartamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, Instituto de Investigación Hospital 12 de Octubre, i+12, 28040 Madrid, SpainDepartamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, Instituto de Investigación Hospital 12 de Octubre, i+12, 28040 Madrid, SpainDepartamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, Instituto de Investigación Hospital 12 de Octubre, i+12, 28040 Madrid, SpainAdvanced bioceramics for bone regeneration constitutes one of the pivotal interests in the multidisciplinary and far-sighted scientific trajectory of Prof. Vallet Regí. The different pathologies that affect osseous tissue substitution are considered to be one of the most important challenges from the health, social and economic point of view. 3D scaffolds based on bioceramics that mimic the composition, environment, microstructure and pore architecture of hard tissues is a consolidated response to such concerns. This review describes not only the different types of materials utilized: from apatite-type to silicon mesoporous materials, but also the fabrication techniques employed to design and adequate microstructure, a hierarchical porosity (from nano to macro scale), a cell-friendly surface; the inclusion of different type of biomolecules, drugs or cells within these scaffolds and the influence on their successful performance is thoughtfully reviewed.https://www.mdpi.com/1999-4923/13/11/1981rapid prototypingGELPOR3Dsilica-hydroxyapatitemesoporous materialsmeso–macroporous scaffoldsceramic modifying agents |
| spellingShingle | Ana García María Victoria Cabañas Juan Peña Sandra Sánchez-Salcedo Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials Pharmaceutics rapid prototyping GELPOR3D silica-hydroxyapatite mesoporous materials meso–macroporous scaffolds ceramic modifying agents |
| title | Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials |
| title_full | Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials |
| title_fullStr | Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials |
| title_full_unstemmed | Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials |
| title_short | Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials |
| title_sort | design of 3d scaffolds for hard tissue engineering from apatites to silicon mesoporous materials |
| topic | rapid prototyping GELPOR3D silica-hydroxyapatite mesoporous materials meso–macroporous scaffolds ceramic modifying agents |
| url | https://www.mdpi.com/1999-4923/13/11/1981 |
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