Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study
Beta-catenin is a major protein in the Wnt signalling pathway. Although it has been studied in various types of carcinoma, little is known about its expression in mesenchymal tumours. In this study 41 specimens of a variety of mesenchymal childhood tumours were compared to 24 samples of the correspo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2012-07-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | http://www.ejh.it/index.php/ejh/article/view/2010 |
| _version_ | 1818210873288687616 |
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| author | A. Santoro G. Pannone M.E. Errico D. Bifano G. Lastilla P. Bufo C. Loreto V. Donofrio |
| author_facet | A. Santoro G. Pannone M.E. Errico D. Bifano G. Lastilla P. Bufo C. Loreto V. Donofrio |
| author_sort | A. Santoro |
| collection | DOAJ |
| description | Beta-catenin is a major protein in the Wnt signalling pathway. Although it has been studied in various types of carcinoma, little is known about its expression in mesenchymal tumours. In this study 41 specimens of a variety of mesenchymal childhood tumours were compared to 24 samples of the corresponding adult tumours to assess the diagnostic value of nuclear β-catenin expression using tissue microarray-based immunohistochemistry. Similar to adult sarcoma and fibromatosis, β-catenin was not expressed in the majority of childhood sarcomas, and its nuclear translocation was detected in paediatric fibromatosis; non-negligible levels of nuclear staining in other tumour types demonstrate Wnt pathway activation in mesenchymal neoplasms of childhood and adolescence. |
| first_indexed | 2024-12-12T05:23:31Z |
| format | Article |
| id | doaj.art-7b82ec3ca76a4d88af003d62d3b9ff56 |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-12T05:23:31Z |
| publishDate | 2012-07-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-7b82ec3ca76a4d88af003d62d3b9ff562022-12-22T00:36:33ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062012-07-01563e25e2510.4081/ejh.2012.e251280Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical studyA. Santoro0G. Pannone1M.E. Errico2D. Bifano3G. Lastilla4P. Bufo5C. Loreto6V. Donofrio7University of FoggiaUniversity of FoggiaPaediatric Oncological Hospital ‘Pausillipon’Paediatric Oncological Hospital ‘Pausillipon’, NapoliUniversity of BariUniversity of FoggiaUniversity of CataniaPaediatric Oncological Hospital ‘Pausillipon’, NapoliBeta-catenin is a major protein in the Wnt signalling pathway. Although it has been studied in various types of carcinoma, little is known about its expression in mesenchymal tumours. In this study 41 specimens of a variety of mesenchymal childhood tumours were compared to 24 samples of the corresponding adult tumours to assess the diagnostic value of nuclear β-catenin expression using tissue microarray-based immunohistochemistry. Similar to adult sarcoma and fibromatosis, β-catenin was not expressed in the majority of childhood sarcomas, and its nuclear translocation was detected in paediatric fibromatosis; non-negligible levels of nuclear staining in other tumour types demonstrate Wnt pathway activation in mesenchymal neoplasms of childhood and adolescence.http://www.ejh.it/index.php/ejh/article/view/2010beta-cateninWnt-pathwayimmunohistochemistrypaediatric mesenchymal tumors |
| spellingShingle | A. Santoro G. Pannone M.E. Errico D. Bifano G. Lastilla P. Bufo C. Loreto V. Donofrio Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study European Journal of Histochemistry beta-catenin Wnt-pathway immunohistochemistry paediatric mesenchymal tumors |
| title | Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study |
| title_full | Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study |
| title_fullStr | Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study |
| title_full_unstemmed | Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study |
| title_short | Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study |
| title_sort | role of β catenin expression in paediatric mesenchymal lesions a tissue microarray based immunohistochemical study |
| topic | beta-catenin Wnt-pathway immunohistochemistry paediatric mesenchymal tumors |
| url | http://www.ejh.it/index.php/ejh/article/view/2010 |
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