Evaluation of dihydrotestosterone and dihydroprogesterone levels and gene expression of genes involved in neurosteroidogenesis in the SH-SY5Y Alzheimer disease cell model

Evaluation of dihydrotestosterone and dihydroprogesterone levels and gene expression of genes involved in neurosteroidogenesis in the SH-SY5Y Alzheimer disease cell model

IntroductionAlzheimer’s disease (AD) is the most common form of dementia worldwide. This study investigated the effects of lipopolysaccharide on neurosteroidogenesis and its relationship to growth and differentiation using SH-SY5Y cells.MethodsIn this study, we used the MTT assay to assess the impac...

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Bibliographic Details
Main Authors: Saeed Radagdam, Fatemeh Khaki-Khatibi, Reza Rahbarghazi, Behrouz Shademan, Seyed Manouchehr Nourazarian, Masoud Nikanfar, Alireza Nourazarian
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
lipopolysaccharide
dihydrotestosterone
dihydroprogesterone
human neurogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1163806/full

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