Comparing salivary antibacterial peptides in children with and without Caries
Background: salivary proteins have, today, gained special importance in studies of the role of saliva in tooth decay. Among the peptides, histatins and defenses play a more important role. The aim of this study was to determine the concentration of salivary antibacterial peptides in children with ea...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-09-01
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| Series: | International Journal of Pediatrics |
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| Online Access: | https://ijp.mums.ac.ir/article_23093_338ea9ef7ea1fbac87e169a6f208531e.pdf |
| _version_ | 1797644694709075968 |
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| author | Bahare Nazemisalman Venous Baheran Mohammad Reza Shokrani Seyede Solmaz Taheri |
| author_facet | Bahare Nazemisalman Venous Baheran Mohammad Reza Shokrani Seyede Solmaz Taheri |
| author_sort | Bahare Nazemisalman |
| collection | DOAJ |
| description | Background: salivary proteins have, today, gained special importance in studies of the role of saliva in tooth decay. Among the peptides, histatins and defenses play a more important role. The aim of this study was to determine the concentration of salivary antibacterial peptides in children with early childhood caries (ECC, SECC) compared to children without caries.
Methods: This comparative-case study was conducted on 48 young children (under 6 years of age) with milk teeth referred to a private pediatric dentistry center. The participants were divided into three groups of 16 with early childhood caries (ECC, SECC) and without decay. After collecting children's saliva, the samples were sent to the laboratory to obtain peptide concentration in salivia using ELISA and the results were analyzed using SPSS 22 software.
Results: The average index of histatin-5 in the mild caries group was significantly lower than those in the moderate caries (p<0.001) and severe caries groups (p<0.001). The average index of beta-defensin-1 in the mild caries group was significantly higher than those in the moderate caries (p<0.001) and severe caries groups (p<0.001). The average beta-defensin-2 index in the mild caries group was significantly higher than those in the moderate caries group (p<0.001); and in the severe caries group, it was significantly higher than that in the moderate caries group (p<0.001).
Conclusion: With the increase of salivary HST-5, the progress of caries increased. Also, the progress of caries was associated with a decrease in the amount of β-defensin-1. No correlation was observed between the caries process and the amount of β-defensin-2. |
| first_indexed | 2024-03-11T14:34:23Z |
| format | Article |
| id | doaj.art-7b83cd972b934faf9392b61010d23175 |
| institution | Directory Open Access Journal |
| issn | 2345-5047 2345-5055 |
| language | English |
| last_indexed | 2024-03-11T14:34:23Z |
| publishDate | 2023-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj.art-7b83cd972b934faf9392b61010d231752023-10-31T05:04:43ZengMashhad University of Medical SciencesInternational Journal of Pediatrics2345-50472345-50552023-09-01119182121821910.22038/ijp.2023.74229.534923093Comparing salivary antibacterial peptides in children with and without CariesBahare Nazemisalman0Venous Baheran1Mohammad Reza Shokrani2Seyede Solmaz Taheri3MScD, Associate Professor of Pediatric Department, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, IranDentist (DDS), School of Dentistry, Islamic Azad University of Isfahan (Khorasgan) Branch, Isfahan, Iran.Dentist (DDS), School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran.PhD candidate, Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Background: salivary proteins have, today, gained special importance in studies of the role of saliva in tooth decay. Among the peptides, histatins and defenses play a more important role. The aim of this study was to determine the concentration of salivary antibacterial peptides in children with early childhood caries (ECC, SECC) compared to children without caries. Methods: This comparative-case study was conducted on 48 young children (under 6 years of age) with milk teeth referred to a private pediatric dentistry center. The participants were divided into three groups of 16 with early childhood caries (ECC, SECC) and without decay. After collecting children's saliva, the samples were sent to the laboratory to obtain peptide concentration in salivia using ELISA and the results were analyzed using SPSS 22 software. Results: The average index of histatin-5 in the mild caries group was significantly lower than those in the moderate caries (p<0.001) and severe caries groups (p<0.001). The average index of beta-defensin-1 in the mild caries group was significantly higher than those in the moderate caries (p<0.001) and severe caries groups (p<0.001). The average beta-defensin-2 index in the mild caries group was significantly higher than those in the moderate caries group (p<0.001); and in the severe caries group, it was significantly higher than that in the moderate caries group (p<0.001). Conclusion: With the increase of salivary HST-5, the progress of caries increased. Also, the progress of caries was associated with a decrease in the amount of β-defensin-1. No correlation was observed between the caries process and the amount of β-defensin-2.https://ijp.mums.ac.ir/article_23093_338ea9ef7ea1fbac87e169a6f208531e.pdfkey words: anti-bacterial agents,,,،dental care for children,,,،dental caries,,,،peptides,,,،saliva |
| spellingShingle | Bahare Nazemisalman Venous Baheran Mohammad Reza Shokrani Seyede Solmaz Taheri Comparing salivary antibacterial peptides in children with and without Caries International Journal of Pediatrics key words: anti-bacterial agents,, ,،dental care for children,, ,،dental caries,, ,،peptides,, ,،saliva |
| title | Comparing salivary antibacterial peptides in children with and without Caries |
| title_full | Comparing salivary antibacterial peptides in children with and without Caries |
| title_fullStr | Comparing salivary antibacterial peptides in children with and without Caries |
| title_full_unstemmed | Comparing salivary antibacterial peptides in children with and without Caries |
| title_short | Comparing salivary antibacterial peptides in children with and without Caries |
| title_sort | comparing salivary antibacterial peptides in children with and without caries |
| topic | key words: anti-bacterial agents,, ,،dental care for children,, ,،dental caries,, ,،peptides,, ,،saliva |
| url | https://ijp.mums.ac.ir/article_23093_338ea9ef7ea1fbac87e169a6f208531e.pdf |
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