Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research

Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research

The identity and role of environmental factors in the etiology of sporadic amyotrophic lateral sclerosis (sALS) is poorly understood outside of three former high-incidence foci of Western Pacific ALS and a hotspot of sALS in the French Alps. In both instances, there is a strong association with expo...

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Bibliographic Details
Main Authors: Peter S. Spencer, Valerie S. Palmer, Glen E. Kisby, Emmeline Lagrange, B. Zane Horowitz, Raquel Valdes Angues, Jacques Reis, Jean-Paul Vernoux, Cédric Raoul, William Camu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Neuroscience
Subjects:
genotoxin
gyromitrin
agaritine
monomethylhydrazine (MMH)
methylazoxymethanol (MAM)
lifetime exposome
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1005096/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1005096/full

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