Endothelial progenitor cells in age-related vascular remodeling
Accumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima. Meanwhile, other findings suggest that EPCs may be involved...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-05-01
|
| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/0963689718779345 |
| _version_ | 1818273998942765056 |
|---|---|
| author | Jin-Xiu Yang Yan-Yun Pan Xing-Xiang Wang Yuan-Gang Qiu Wei Mao |
| author_facet | Jin-Xiu Yang Yan-Yun Pan Xing-Xiang Wang Yuan-Gang Qiu Wei Mao |
| author_sort | Jin-Xiu Yang |
| collection | DOAJ |
| description | Accumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima. Meanwhile, other findings suggest that EPCs may be involved in the pathogenesis of age-related vascular remodeling. This review is presented to summarize the characteristics of EPCs and age-related vascular remodeling. In addition, the role of EPCs in age-related vascular remodeling and possible solutions for improving the therapeutic effects of EPCs in the treatment of age-related diseases are discussed. |
| first_indexed | 2024-12-12T22:06:52Z |
| format | Article |
| id | doaj.art-7b8638da699b4720bffcfedb09238e67 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-12T22:06:52Z |
| publishDate | 2018-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-7b8638da699b4720bffcfedb09238e672022-12-22T00:10:21ZengSAGE PublishingCell Transplantation0963-68971555-38922018-05-012710.1177/0963689718779345Endothelial progenitor cells in age-related vascular remodelingJin-Xiu Yang0Yan-Yun Pan1Xing-Xiang Wang2Yuan-Gang Qiu3Wei Mao4 Department of Cardiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, P.R. China Department of Cardiology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, P.R. China Department of Cardiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, P.R. China Department of Cardiology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, P.R. China Department of Cardiology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, P.R. ChinaAccumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima. Meanwhile, other findings suggest that EPCs may be involved in the pathogenesis of age-related vascular remodeling. This review is presented to summarize the characteristics of EPCs and age-related vascular remodeling. In addition, the role of EPCs in age-related vascular remodeling and possible solutions for improving the therapeutic effects of EPCs in the treatment of age-related diseases are discussed.https://doi.org/10.1177/0963689718779345 |
| spellingShingle | Jin-Xiu Yang Yan-Yun Pan Xing-Xiang Wang Yuan-Gang Qiu Wei Mao Endothelial progenitor cells in age-related vascular remodeling Cell Transplantation |
| title | Endothelial progenitor cells in age-related vascular remodeling |
| title_full | Endothelial progenitor cells in age-related vascular remodeling |
| title_fullStr | Endothelial progenitor cells in age-related vascular remodeling |
| title_full_unstemmed | Endothelial progenitor cells in age-related vascular remodeling |
| title_short | Endothelial progenitor cells in age-related vascular remodeling |
| title_sort | endothelial progenitor cells in age related vascular remodeling |
| url | https://doi.org/10.1177/0963689718779345 |
| work_keys_str_mv | AT jinxiuyang endothelialprogenitorcellsinagerelatedvascularremodeling AT yanyunpan endothelialprogenitorcellsinagerelatedvascularremodeling AT xingxiangwang endothelialprogenitorcellsinagerelatedvascularremodeling AT yuangangqiu endothelialprogenitorcellsinagerelatedvascularremodeling AT weimao endothelialprogenitorcellsinagerelatedvascularremodeling |