A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.

A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.

The PTEN tumour suppressor encodes a phosphatase, and its daf-18 orthologue in Caenorhabditis elegans negatively regulates the insulin/IGF-1 DAF-2 receptor pathway that influences lifespan in worms and other species. In order to identify new DAF-18 regulated pathways involved in aging, we initiated...

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Bibliographic Details
Main Authors: Ingrid Masse, Laurent Molin, Laurent Mouchiroud, Philippe Vanhems, Francesca Palladino, Marc Billaud, Florence Solari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2556085?pdf=render

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