Effect of Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetes
Objective This study was designed to evaluate the protective effect of aqueous extract of Solanum macrocarpon Linn leaf in the brain of an alloxan-induced rat model of diabetes. Methods The experimental model of diabetes was induced by a single intraperitoneal injection of freshly prepared alloxan....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-06-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520922649 |
| _version_ | 1818938122471211008 |
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| author | Mary A. Okesola Basiru O. Ajiboye Babatunji E. Oyinloye Olukemi A. Osukoya Ofogho S. Owero-ozeze Lisa I. Ekakitie Abidemi P. Kappo |
| author_facet | Mary A. Okesola Basiru O. Ajiboye Babatunji E. Oyinloye Olukemi A. Osukoya Ofogho S. Owero-ozeze Lisa I. Ekakitie Abidemi P. Kappo |
| author_sort | Mary A. Okesola |
| collection | DOAJ |
| description | Objective This study was designed to evaluate the protective effect of aqueous extract of Solanum macrocarpon Linn leaf in the brain of an alloxan-induced rat model of diabetes. Methods The experimental model of diabetes was induced by a single intraperitoneal injection of freshly prepared alloxan. Rats were then divided into six groups: normal control, diabetes control, diabetes group treated with metformin, and three diabetes groups treated with different concentrations of S. macrocarpon . Rats were sacrificed on day 14 of the experiment and different brain biochemical parameters were assessed and compared between groups. Results Administration of different doses of S. macrocarpon leaf aqueous extract was associated with significantly reduced levels of fasting blood glucose, lipid peroxidation, neurotransmitters, cholinesterases, cyclooxygenase-2 and nitric oxide compared with diabetes control rats. In addition, antioxidant enzyme activities were significantly increased in diabetes rats administered 12.45, 24.9 and 49.8 mg/kg body weight of S. macrocarpon versus diabetes control rats. Conclusion Aqueous extract of S. macrocarpon Linn leaf may be useful in the management of diabetic neuropathy. |
| first_indexed | 2024-12-20T06:02:50Z |
| format | Article |
| id | doaj.art-7b87d5abe32c4160827898010b6adade |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-20T06:02:50Z |
| publishDate | 2020-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-7b87d5abe32c4160827898010b6adade2022-12-21T19:50:52ZengSAGE PublishingJournal of International Medical Research1473-23002020-06-014810.1177/0300060520922649Effect of Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetesMary A. OkesolaBasiru O. AjiboyeBabatunji E. OyinloyeOlukemi A. OsukoyaOfogho S. Owero-ozezeLisa I. EkakitieAbidemi P. KappoObjective This study was designed to evaluate the protective effect of aqueous extract of Solanum macrocarpon Linn leaf in the brain of an alloxan-induced rat model of diabetes. Methods The experimental model of diabetes was induced by a single intraperitoneal injection of freshly prepared alloxan. Rats were then divided into six groups: normal control, diabetes control, diabetes group treated with metformin, and three diabetes groups treated with different concentrations of S. macrocarpon . Rats were sacrificed on day 14 of the experiment and different brain biochemical parameters were assessed and compared between groups. Results Administration of different doses of S. macrocarpon leaf aqueous extract was associated with significantly reduced levels of fasting blood glucose, lipid peroxidation, neurotransmitters, cholinesterases, cyclooxygenase-2 and nitric oxide compared with diabetes control rats. In addition, antioxidant enzyme activities were significantly increased in diabetes rats administered 12.45, 24.9 and 49.8 mg/kg body weight of S. macrocarpon versus diabetes control rats. Conclusion Aqueous extract of S. macrocarpon Linn leaf may be useful in the management of diabetic neuropathy.https://doi.org/10.1177/0300060520922649 |
| spellingShingle | Mary A. Okesola Basiru O. Ajiboye Babatunji E. Oyinloye Olukemi A. Osukoya Ofogho S. Owero-ozeze Lisa I. Ekakitie Abidemi P. Kappo Effect of Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetes Journal of International Medical Research |
| title | Effect of Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetes |
| title_full | Effect of Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetes |
| title_fullStr | Effect of Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetes |
| title_full_unstemmed | Effect of Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetes |
| title_short | Effect of Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetes |
| title_sort | effect of linn leaf aqueous extract on the brain of an alloxan induced rat model of diabetes |
| url | https://doi.org/10.1177/0300060520922649 |
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