Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s disease
Abstract Background Non-motor symptoms are an important early feature of Parkinson’s disease (PD), encompassing a variety of cognitive and psychiatric symptoms that seem to manifest differently depending on motor symptom asymmetry. Different factors, such as uric acid (UA) and sex, seem to influence...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-023-00510-1 |
| _version_ | 1797832230410649600 |
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| author | Ioana Medeleine Constantin Philippe Voruz Julie Anne Péron |
| author_facet | Ioana Medeleine Constantin Philippe Voruz Julie Anne Péron |
| author_sort | Ioana Medeleine Constantin |
| collection | DOAJ |
| description | Abstract Background Non-motor symptoms are an important early feature of Parkinson’s disease (PD), encompassing a variety of cognitive and psychiatric symptoms that seem to manifest differently depending on motor symptom asymmetry. Different factors, such as uric acid (UA) and sex, seem to influence cognitive and psychiatric expression in PD, however their interplay remains to be better understood. Methods Participants taking part in the Parkinson’s Progression Marker Initiative were studied based on the side of motor symptom asymmetry and sex. Three-way interaction modeling was used to examine the moderating effects of sex and UA on cognitive functions and psychiatric symptoms. Results Significant three-way interactions were highlighted at 1-year follow-up between motor symptom asymmetry, UA and sex for immediate and long-term memory in female patients exhibiting predominantly left-sided motor symptoms, and for processing speed and sleepiness in female patients exhibiting predominantly right-sided motor symptoms. No significant interactions were observed for male patients. Moreover, female patients exhibiting predominantly right-sided motor symptoms demonstrated lower serum UA concentrations and had overall better outcomes, while male patients with predominantly right-sided motor symptoms demonstrated particularly poor outcomes. Conclusions These findings suggest that in the earliest stages of the disease, UA and sex moderate cognitive functions and psychiatric symptoms differently depending on motor asymmetry, holding important clinical implications for symptom management in patients. |
| first_indexed | 2024-04-09T14:05:33Z |
| format | Article |
| id | doaj.art-7b88036acd084c8c8f2ea661abfe8144 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-09T14:05:33Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-7b88036acd084c8c8f2ea661abfe81442023-05-07T11:03:32ZengBMCBiology of Sex Differences2042-64102023-05-0114111110.1186/s13293-023-00510-1Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s diseaseIoana Medeleine Constantin0Philippe Voruz1Julie Anne Péron2Clinical and Experimental Neuropsychology Laboratory, Faculty of Psychology and Educational Sciences, University of GenevaClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology and Educational Sciences, University of GenevaClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology and Educational Sciences, University of GenevaAbstract Background Non-motor symptoms are an important early feature of Parkinson’s disease (PD), encompassing a variety of cognitive and psychiatric symptoms that seem to manifest differently depending on motor symptom asymmetry. Different factors, such as uric acid (UA) and sex, seem to influence cognitive and psychiatric expression in PD, however their interplay remains to be better understood. Methods Participants taking part in the Parkinson’s Progression Marker Initiative were studied based on the side of motor symptom asymmetry and sex. Three-way interaction modeling was used to examine the moderating effects of sex and UA on cognitive functions and psychiatric symptoms. Results Significant three-way interactions were highlighted at 1-year follow-up between motor symptom asymmetry, UA and sex for immediate and long-term memory in female patients exhibiting predominantly left-sided motor symptoms, and for processing speed and sleepiness in female patients exhibiting predominantly right-sided motor symptoms. No significant interactions were observed for male patients. Moreover, female patients exhibiting predominantly right-sided motor symptoms demonstrated lower serum UA concentrations and had overall better outcomes, while male patients with predominantly right-sided motor symptoms demonstrated particularly poor outcomes. Conclusions These findings suggest that in the earliest stages of the disease, UA and sex moderate cognitive functions and psychiatric symptoms differently depending on motor asymmetry, holding important clinical implications for symptom management in patients.https://doi.org/10.1186/s13293-023-00510-1Parkinson’s diseaseMotor symptom asymmetryCognitionPsychiatric symptomsUric acidThree-way interaction models |
| spellingShingle | Ioana Medeleine Constantin Philippe Voruz Julie Anne Péron Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s disease Biology of Sex Differences Parkinson’s disease Motor symptom asymmetry Cognition Psychiatric symptoms Uric acid Three-way interaction models |
| title | Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s disease |
| title_full | Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s disease |
| title_fullStr | Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s disease |
| title_full_unstemmed | Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s disease |
| title_short | Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s disease |
| title_sort | moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric parkinson s disease |
| topic | Parkinson’s disease Motor symptom asymmetry Cognition Psychiatric symptoms Uric acid Three-way interaction models |
| url | https://doi.org/10.1186/s13293-023-00510-1 |
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