Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine Tumour
Ectopic production of adrenocorticotropic hormone (ACTH) by gastrointestinal neuroendocrine tumours (NETs) is relatively uncommon. We report a rare case of a liver metastatic G1 low-grade NET of the intestine that induced hypercortisolism after surgical resection. A 50-year-old man was admitted for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-09-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/518316 |
| _version_ | 1818742504727511040 |
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| author | Laurent Mineur Rania Boustany Léa Vazquez |
| author_facet | Laurent Mineur Rania Boustany Léa Vazquez |
| author_sort | Laurent Mineur |
| collection | DOAJ |
| description | Ectopic production of adrenocorticotropic hormone (ACTH) by gastrointestinal neuroendocrine tumours (NETs) is relatively uncommon. We report a rare case of a liver metastatic G1 low-grade NET of the intestine that induced hypercortisolism after surgical resection. A 50-year-old man was admitted for an intestinal obstruction caused by a tumour of the intestine. Paraneoplastic Cushing syndrome was diagnosed more than a year later following the appearance of cushingoid symptoms, despite stable disease according to RECIST criteria but chromogranin A increase. Ketoconazole and sandostatin medical treatment and liver chemoembolization never managed to control the hypercortisolism unlike the bilateral adrenalectomy. The identification and effective management of this uncommon statement of ectopic ACTH secretion is important to improve the patient’s prognosis and quality of life. |
| first_indexed | 2024-12-18T02:13:34Z |
| format | Article |
| id | doaj.art-7b89a3e004974d13ae0c5563c788087b |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-18T02:13:34Z |
| publishDate | 2021-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-7b89a3e004974d13ae0c5563c788087b2022-12-21T21:24:26ZengKarger PublishersCase Reports in Oncology1662-65752021-09-011431407141310.1159/000518316518316Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine TumourLaurent MineurRania BoustanyLéa VazquezEctopic production of adrenocorticotropic hormone (ACTH) by gastrointestinal neuroendocrine tumours (NETs) is relatively uncommon. We report a rare case of a liver metastatic G1 low-grade NET of the intestine that induced hypercortisolism after surgical resection. A 50-year-old man was admitted for an intestinal obstruction caused by a tumour of the intestine. Paraneoplastic Cushing syndrome was diagnosed more than a year later following the appearance of cushingoid symptoms, despite stable disease according to RECIST criteria but chromogranin A increase. Ketoconazole and sandostatin medical treatment and liver chemoembolization never managed to control the hypercortisolism unlike the bilateral adrenalectomy. The identification and effective management of this uncommon statement of ectopic ACTH secretion is important to improve the patient’s prognosis and quality of life.https://www.karger.com/Article/FullText/518316ectopic cushing syndromeneuroendocrine tumourswho grade 1paraneoplastic syndromeschromogranin a |
| spellingShingle | Laurent Mineur Rania Boustany Léa Vazquez Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine Tumour Case Reports in Oncology ectopic cushing syndrome neuroendocrine tumours who grade 1 paraneoplastic syndromes chromogranin a |
| title | Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine Tumour |
| title_full | Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine Tumour |
| title_fullStr | Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine Tumour |
| title_full_unstemmed | Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine Tumour |
| title_short | Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine Tumour |
| title_sort | paraneoplastic cushing syndrome in gastrointestinal neuroendocrine tumour |
| topic | ectopic cushing syndrome neuroendocrine tumours who grade 1 paraneoplastic syndromes chromogranin a |
| url | https://www.karger.com/Article/FullText/518316 |
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