pH-Responsive Rheological Properties and Microstructure Transition in Mixture of Anionic Gemini/Cationic Monomeric Surfactants
Surfactant aggregates have long been considered as a tool to improve drug delivery and have been widely used in medical products. The pH-responsive aggregation behavior in anionic gemini surfactant 1,3-bis(<i>N</i>-dodecyl-<i>N</i>-propanesulfonate sodium)-propane (C<sub&g...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/16/5013 |
| _version_ | 1797522707209781248 |
|---|---|
| author | Maozhang Tian Xi Chen Xinyuan Zou Yuchen Qian Zhang Liu Yaxun Fan |
| author_facet | Maozhang Tian Xi Chen Xinyuan Zou Yuchen Qian Zhang Liu Yaxun Fan |
| author_sort | Maozhang Tian |
| collection | DOAJ |
| description | Surfactant aggregates have long been considered as a tool to improve drug delivery and have been widely used in medical products. The pH-responsive aggregation behavior in anionic gemini surfactant 1,3-bis(<i>N</i>-dodecyl-<i>N</i>-propanesulfonate sodium)-propane (C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub>) and its mixture with a cationic monomeric surfactant cetyltrimethylammonium bromide (CTAB) have been investigated. The spherical-to-wormlike micelle transition was successfully realized in C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub> through decreasing the pH, while the rheological properties were perfectly enhanced for the formation of wormlike micelles. Especially at 140 mM and pH 6.7, the mixture showed high viscoelasticity, and the maximum of the zero-shear viscosity reached 1530 Pa·s. Acting as a sulfobetaine zwitterionic gemini surfactant, the electrostatic attraction, the hydrogen bond and the short spacer of C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub> molecules were all responsible for the significant micellar growth. Upon adding CTAB, the similar transition could also be realized at a low pH, and the further transformation to branched micelles occurred by adjusting the total concentration. Although the mixtures did not approach the viscosity maximum appearing in the C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub> solution, CTAB addition is more favorable for viscosity enhancement in the wormlike-micelle region. The weakened charges of the headgroups in a catanionic mixed system minimizes the micellar spontaneous curvature and enhances the intermolecular hydrogen-bonding interaction between C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub>, facilitating the formation of a viscous solution, which would greatly induce entanglement and even the fusion of wormlike micelles, thus resulting in branched microstructures and a decline of viscosity. |
| first_indexed | 2024-03-10T08:33:14Z |
| format | Article |
| id | doaj.art-7b8abebc43f040509409ae47f83b0666 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T08:33:14Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7b8abebc43f040509409ae47f83b06662023-11-22T08:55:20ZengMDPI AGMolecules1420-30492021-08-012616501310.3390/molecules26165013pH-Responsive Rheological Properties and Microstructure Transition in Mixture of Anionic Gemini/Cationic Monomeric SurfactantsMaozhang Tian0Xi Chen1Xinyuan Zou2Yuchen Qian3Zhang Liu4Yaxun Fan5State Key Laboratory of Enhanced Oil Recovery, Research Institute of Petroleum Exploration and Development, CNPC, Beijing 100083, ChinaState Key Laboratory of Enhanced Oil Recovery, Research Institute of Petroleum Exploration and Development, CNPC, Beijing 100083, ChinaState Key Laboratory of Enhanced Oil Recovery, Research Institute of Petroleum Exploration and Development, CNPC, Beijing 100083, ChinaState Key Laboratory of Enhanced Oil Recovery, Research Institute of Petroleum Exploration and Development, CNPC, Beijing 100083, ChinaCAS Key Laboratory of Colloid, Interface Thermodynamics, Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaCAS Key Laboratory of Colloid, Interface Thermodynamics, Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaSurfactant aggregates have long been considered as a tool to improve drug delivery and have been widely used in medical products. The pH-responsive aggregation behavior in anionic gemini surfactant 1,3-bis(<i>N</i>-dodecyl-<i>N</i>-propanesulfonate sodium)-propane (C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub>) and its mixture with a cationic monomeric surfactant cetyltrimethylammonium bromide (CTAB) have been investigated. The spherical-to-wormlike micelle transition was successfully realized in C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub> through decreasing the pH, while the rheological properties were perfectly enhanced for the formation of wormlike micelles. Especially at 140 mM and pH 6.7, the mixture showed high viscoelasticity, and the maximum of the zero-shear viscosity reached 1530 Pa·s. Acting as a sulfobetaine zwitterionic gemini surfactant, the electrostatic attraction, the hydrogen bond and the short spacer of C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub> molecules were all responsible for the significant micellar growth. Upon adding CTAB, the similar transition could also be realized at a low pH, and the further transformation to branched micelles occurred by adjusting the total concentration. Although the mixtures did not approach the viscosity maximum appearing in the C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub> solution, CTAB addition is more favorable for viscosity enhancement in the wormlike-micelle region. The weakened charges of the headgroups in a catanionic mixed system minimizes the micellar spontaneous curvature and enhances the intermolecular hydrogen-bonding interaction between C<sub>12</sub>C<sub>3</sub>C<sub>12</sub>(SO<sub>3</sub>)<sub>2</sub>, facilitating the formation of a viscous solution, which would greatly induce entanglement and even the fusion of wormlike micelles, thus resulting in branched microstructures and a decline of viscosity.https://www.mdpi.com/1420-3049/26/16/5013gemini surfactantmicellar growthwormlike micelleentanglementviscoelasticity |
| spellingShingle | Maozhang Tian Xi Chen Xinyuan Zou Yuchen Qian Zhang Liu Yaxun Fan pH-Responsive Rheological Properties and Microstructure Transition in Mixture of Anionic Gemini/Cationic Monomeric Surfactants Molecules gemini surfactant micellar growth wormlike micelle entanglement viscoelasticity |
| title | pH-Responsive Rheological Properties and Microstructure Transition in Mixture of Anionic Gemini/Cationic Monomeric Surfactants |
| title_full | pH-Responsive Rheological Properties and Microstructure Transition in Mixture of Anionic Gemini/Cationic Monomeric Surfactants |
| title_fullStr | pH-Responsive Rheological Properties and Microstructure Transition in Mixture of Anionic Gemini/Cationic Monomeric Surfactants |
| title_full_unstemmed | pH-Responsive Rheological Properties and Microstructure Transition in Mixture of Anionic Gemini/Cationic Monomeric Surfactants |
| title_short | pH-Responsive Rheological Properties and Microstructure Transition in Mixture of Anionic Gemini/Cationic Monomeric Surfactants |
| title_sort | ph responsive rheological properties and microstructure transition in mixture of anionic gemini cationic monomeric surfactants |
| topic | gemini surfactant micellar growth wormlike micelle entanglement viscoelasticity |
| url | https://www.mdpi.com/1420-3049/26/16/5013 |
| work_keys_str_mv | AT maozhangtian phresponsiverheologicalpropertiesandmicrostructuretransitioninmixtureofanionicgeminicationicmonomericsurfactants AT xichen phresponsiverheologicalpropertiesandmicrostructuretransitioninmixtureofanionicgeminicationicmonomericsurfactants AT xinyuanzou phresponsiverheologicalpropertiesandmicrostructuretransitioninmixtureofanionicgeminicationicmonomericsurfactants AT yuchenqian phresponsiverheologicalpropertiesandmicrostructuretransitioninmixtureofanionicgeminicationicmonomericsurfactants AT zhangliu phresponsiverheologicalpropertiesandmicrostructuretransitioninmixtureofanionicgeminicationicmonomericsurfactants AT yaxunfan phresponsiverheologicalpropertiesandmicrostructuretransitioninmixtureofanionicgeminicationicmonomericsurfactants |