High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of secondary dengue virus infection.

High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of secondary dengue virus infection.

BACKGROUND:Dengue is one of the most important human diseases transmitted by an arthropod vector and the incidence of dengue virus infection has been increasing - over half the world's population now live in areas at risk of infection. Most infections are asymptomatic, but a subset of patients...

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Main Authors: Tao Dong, Edward Moran, Nguyen Vinh Chau, Cameron Simmons, Kerstin Luhn, Yanchun Peng, Bridget Wills, Nguyen Phuong Dung, Le Thi Thu Thao, Tran Tinh Hien, Andrew McMichael, Jeremy Farrar, Sarah Rowland-Jones
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2092391?pdf=render

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