Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

Stimulating broadly neutralizing antibodies (bnAbs) directly from germline remains a barrier for HIV vaccines. HIV superinfection elicits bnAbs more frequently than single infection, providing clues of how to elicit such responses. We used longitudinal antibody sequencing and structural studies to c...

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Bibliographic Details
Main Authors: Mackenzie M Shipley, Vidya Mangala Prasad, Laura E Doepker, Adam Dingens, Duncan K Ralph, Elias Harkins, Amrit Dhar, Dana Arenz, Vrasha Chohan, Haidyn Weight, Kishor Mandaliya, Jesse D Bloom, Frederick A Matsen IV, Kelly K Lee, Julie M Overbaugh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
HIV
broadly neutralizing antibody
V3
superinfection
cryo-EM
lineage development
Online Access:https://elifesciences.org/articles/68110

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